在接受种植体支持治疗的患者中，根据种植体周围疾病的微生物学和基质金属蛋白酶-8的研究结果
Microbiological and aMMP-8 findings depending on peri-implant disease in patients undergoing supportive implant therapy.
作者信息
Ziebolz Dirk, Schmalz Gerhard, Gollasch Daniel, Eickholz Peter, Rinke Sven
机构信息
Dept. of Cariology, Endodontology, and Periodontology, University Leipzig, Germany.
Dept. of Cariology, Endodontology, and Periodontology, University Leipzig, Germany.
出版信息
Diagn Microbiol Infect Dis. 2017 May;88(1):47-52. doi: 10.1016/j.diagmicrobio.2017.02.008. Epub 2017 Feb 21.
The aim of this study was to evaluate microbiological findings and aMMP-8 level of peri-implant mucositis (M) and peri-implantitis (P) in patients undergoing supportive implant therapy (SIT). Eighty-nine patients with 171 implants were included. The case definitions were as follows: M: PPD ≥4mm, BOP; P: PPD≥4mm, BOP, radiographic bone loss ≥3.5mm. Samples of peri-implant sulcular fluid (PISF) were taken from all peri-implant pockets at each implant to detect periodontal pathogens using PCR and aMMP-8 level with ELISA. Only Treponema denticola (Td) and Prevotella intermedia (Pi) showed significantly higher prevalence in P (healthy implants [HI]: Td=27%, Pi=17%; M: Td=26%, Pi=15%; P: Td and Pi=50%; P<0.05). The mean aMMP-8 level at implant sites did not show any significant difference (P=0.05) among HI (5.2±8.1), M (9.9±19.0), and P (4.9±7.7). Microbiological findings and aMMP-8 levels are not reliable criteria to distinguish between HI, M, and P in patients undergoing SIT.
本研究旨在评估接受种植体支持治疗（SIT）的患者中种植体周围黏膜炎（M）和种植体周围炎（P）的微生物学检查结果及基质金属蛋白酶-8（aMMP-8）水平。纳入了89例患者的171颗种植体。病例定义如下：M：探诊深度（PPD）≥4mm，探诊出血（BOP）；P：PPD≥4mm，BOP，影像学骨吸收≥3.5mm。从每个种植体的所有种植体周围袋中采集种植体周围龈沟液（PISF）样本，采用聚合酶链反应（PCR）检测牙周病原体，并采用酶联免疫吸附测定（ELISA）检测aMMP-8水平。仅具核梭杆菌（Td）和中间普氏菌（Pi）在P组中的患病率显著更高（健康种植体[HI]：Td = 27%，Pi = 17%；M组：Td = 26%，Pi = 15%；P组：Td和Pi = 50%；P<0.05）。种植体部位的平均aMMP-8水平在HI组（5.2±8.1）、M组（9.9±19.0）和P组（4.9±7.7）之间未显示出任何显著差异（P = 0.05）。微生物学检查结果和aMMP-8水平并非区分接受SIT患者的HI、M和P的可靠标准。
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