Ridley A, Kennard C, Scholtz C L, Büttner-Ennever J A, Summers B, Turnbull A
Section of Neurological Science, London Hospital, UK.
Brain. 1987 Dec;110 ( Pt 6):1699-709. doi: 10.1093/brain/110.6.1699.
Opsoclonus is an involuntary eye movement disorder in which there are chaotic, usually conjugate, multidimensional saccadic eye movements. In this paper 2 cases of opsoclonus are reported, as a paraneoplastic phenomenon in association with oat cell carcinoma of the lung. It has previously been hypothesized that opsoclonus results from dysfunction of a group of premotor neurons in the brainstem called omnipause neurons. We describe the location of these cells in man by homology with animal studies, and describe the light microscopic appearance of these neurons in the 2 cases of opsoclonus. Although these neurons appeared normal it is still possible that their function was disturbed as a result of metabolic or neurotransmitter abnormalities.
眼阵挛是一种非自主性眼球运动障碍，其特征为存在混乱的、通常为共轭的多维度眼球跳动性运动。本文报告了2例眼阵挛病例，它们作为一种副肿瘤现象与肺燕麦细胞癌相关。此前曾有假说认为，眼阵挛是由脑干中一组称为全暂停神经元的运动前神经元功能障碍所致。我们通过与动物研究进行类比来描述这些细胞在人体中的位置，并描述这2例眼阵挛病例中这些神经元的光学显微镜下表现。尽管这些神经元外观正常，但它们的功能仍有可能因代谢或神经递质异常而受到干扰。
