Woestenenk Janna W, Schulkes Dorothea A, Schipper Henk S, van der Ent Cornelis K, Houwen Roderick H J
Internal Medicine and Dermatology, Dietetics and, Cystic Fibrosis Centre Utrecht, University Medical Centre Utrecht, KH.01.419.0, P.O. Box 85500, 3508 GA Utrecht, The Netherlands.
Department of Paediatric Gastroenterology, and Cystic Fibrosis Centre, University Medical Centre Utrecht, KE.04.133.1, P.O. Box 85500, 3508 GA Utrecht, The Netherlands.
J Cyst Fibros. 2017 May;16(3):410-417. doi: 10.1016/j.jcf.2017.02.010. Epub 2017 Mar 7.
Cystic fibrosis (CF) patients are advised to derive 35% of their daily energy intake from dietary fat. Whether this high fat intake is associated with dyslipidaemia is unknown. We described the lipid profile and dietary intake in paediatric patients with CF.
110 fasting lipid concentrations of 110 Dutch patients with CF were studied, along with 86 measurements of dietary intake. For the total group and for boys and girls separately, the lipid profile and the dietary intake were investigated. The cross-sectional relationship between the lipid concentrations and dietary intake was determined.
The mean dietary fat intake was ≥35% of the total energy intake, along with a considerable consumption of saturated fat. We found lower concentrations of cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol, and increased concentrations of triglyceride and triglyceride to high-density lipoprotein cholesterol ratios. Lipid concentrations were not associated with dietary fat intake.
This study lacks variation in dietary fat intake to exclude an effect on lipid concentrations as the distribution of dietary fat intake remained constant at a high level. Elevated triglyceride concentrations and triglyceride to high-density lipoprotein cholesterol ratios suggest an increased risk of cardiovascular disease. Any negative consequences of a high dietary fat intake on the overall lipid profile later in life cannot be excluded.
建议囊性纤维化（CF）患者每日能量摄入的35%来自膳食脂肪。这种高脂肪摄入是否与血脂异常有关尚不清楚。我们描述了CF儿科患者的血脂情况和膳食摄入。
研究了110名荷兰CF患者的110次空腹血脂浓度，以及86次膳食摄入测量。分别对总群体以及男孩和女孩的血脂情况和膳食摄入进行了调查。确定了血脂浓度与膳食摄入之间的横断面关系。
平均膳食脂肪摄入量≥总能量摄入的35%，同时饱和脂肪的消耗量也相当可观。我们发现胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇浓度较低，甘油三酯浓度以及甘油三酯与高密度脂蛋白胆固醇的比率升高。血脂浓度与膳食脂肪摄入无关。
本研究中膳食脂肪摄入缺乏变化，无法排除对血脂浓度的影响，因为膳食脂肪摄入分布在高水平保持恒定。甘油三酯浓度升高以及甘油三酯与高密度脂蛋白胆固醇的比率表明心血管疾病风险增加。不能排除高膳食脂肪摄入在生命后期对总体血脂情况产生的任何负面影响。
