Andersson Jesper L R, Graham Mark S, Drobnjak Ivana, Zhang Hui, Filippini Nicola, Bastiani Matteo
FMRIB Centre, Oxford University, Oxford, United Kingdom.
Centre for Medical Image Computing & Department of Computer Science, University College London, London, United Kingdom.
Neuroimage. 2017 May 15;152:450-466. doi: 10.1016/j.neuroimage.2017.02.085. Epub 2017 Mar 8.
Most motion correction methods work by aligning a set of volumes together, or to a volume that represents a reference location. These are based on an implicit assumption that the subject remains motionless during the several seconds it takes to acquire all slices in a volume, and that any movement occurs in the brief moment between acquiring the last slice of one volume and the first slice of the next. This is clearly an approximation that can be more or less good depending on how long it takes to acquire one volume and in how rapidly the subject moves. In this paper we present a method that increases the temporal resolution of the motion correction by modelling movement as a piecewise continous function over time. This intra-volume movement correction is implemented within a previously presented framework that simultaneously estimates distortions, movement and movement-induced signal dropout. We validate the method on highly realistic simulated data containing all of these effects. It is demonstrated that we can estimate the true movement with high accuracy, and that scalar parameters derived from the data, such as fractional anisotropy, are estimated with greater fidelity when data has been corrected for intra-volume movement. Importantly, we also show that the difference in fidelity between data affected by different amounts of movement is much reduced when taking intra-volume movement into account. Additional validation was performed on data from a healthy volunteer scanned when lying still and when performing deliberate movements. We show an increased correspondence between the "still" and the "movement" data when the latter is corrected for intra-volume movement. Finally we demonstrate a big reduction in the telltale signs of intra-volume movement in data acquired on elderly subjects.
大多数运动校正方法是通过将一组容积数据对齐在一起,或者与代表参考位置的容积数据对齐来实现的。这些方法基于一个隐含的假设,即在获取一个容积数据中的所有切片所需的几秒钟内,受试者保持静止,并且任何运动都发生在获取一个容积数据的最后一个切片与下一个容积数据的第一个切片之间的短暂时刻。显然,这是一种近似,其好坏程度取决于获取一个容积数据所需的时间以及受试者运动的速度。在本文中,我们提出了一种方法,通过将运动建模为随时间的分段连续函数来提高运动校正的时间分辨率。这种容积内运动校正实现在先前提出的一个框架内,该框架同时估计失真、运动和运动引起的信号丢失。我们在包含所有这些效应的高度逼真的模拟数据上验证了该方法。结果表明,我们能够高精度地估计真实运动,并且当对容积内运动进行校正后,从数据中导出的标量参数(如分数各向异性)的估计更加准确。重要的是,我们还表明,考虑容积内运动时,受不同运动量影响的数据在准确性上的差异会大大减小。我们还对一名健康志愿者在静止躺着和进行刻意运动时扫描的数据进行了额外验证。当对“运动”数据进行容积内运动校正后,我们发现“静止”数据与“运动”数据之间的对应性有所提高。最后,我们证明了在老年受试者采集的数据中,容积内运动的明显迹象大幅减少。