Kannemeyer J R, Brooks L A, Dumbell K R, Keen G A
Department of Medical Microbiology, University of Cape Town, South Africa.
J Med Virol. 1988 Jan;24(1):101-8. doi: 10.1002/jmv.1890240113.
Adenovirus type 7 is the type most frequently associated with serious disease. Eighteen different genome types of adenovirus type 7 had been reported up to October 1986. The genome type Ad7c, based on the restriction enzyme profiles of SmaI and BamHI, has been reported from Europe prior to 1969 and more recently from South Africa. Here, we report two new genome types of adenovirus 7 c that have not previously been identified and that have been isolated in South Africa between 1975 and 1986 from children with postmeasles pneumonia. The two new genome types differ from the prototype Ad7c virus in having two (Ad7c1) or one (Ad7c2) extra cleavage sites for the restriction endonuclease EcoRI. These sites have been located at 3.68kb and 5.32kb from the left terminus of the genome map published for the prototype Ad7c strain. A strain resembling the prototype Ad7c was also isolated in 1986 from a case of post measles pneumonia.
7型腺病毒是最常与严重疾病相关的类型。截至1986年10月，已报道了18种不同基因组类型的7型腺病毒。基于SmaI和BamHI限制性内切酶图谱的Ad7c基因组类型，早在1969年之前就在欧洲有报道，最近在南非也有报道。在此，我们报告两种新的7型腺病毒c基因组类型，此前未被鉴定，于1975年至1986年期间在南非从患麻疹后肺炎的儿童中分离得到。这两种新基因组类型与原型Ad7c病毒的不同之处在于，它们对于限制性内切酶EcoRI有两个（Ad7c1）或一个（Ad7c2）额外的切割位点。这些位点位于为原型Ad7c菌株公布的基因组图谱左末端3.68kb和5.32kb处。1986年，从一例麻疹后肺炎病例中还分离出了一株类似原型Ad7c的菌株。
