运用代谢组学揭示传统草药的抗癌机制。
Unravelling the Anticancer Mechanisms of Traditional Herbal Medicines with Metabolomics.
机构信息
Oxidative Stress Research Centre, Phytomedicine and Phytochemistry Group, Department of Biomedical Sciences, Cape Peninsula University of Technology, P.O. Box 1906, Bellville 7535, South Africa.
Functional Foods Research Unit, Faculty of Applied Sciences, Cape Peninsula University of Technology, P.O. Box 1906, Bellville 7535, South Africa.
出版信息
Molecules. 2021 Oct 29;26(21):6541. doi: 10.3390/molecules26216541.
Metabolite profiling of cancer cells presents many opportunities for anticancer drug discovery. The Chinese, Indian, and African flora, in particular, offers a diverse source of anticancer therapeutics as documented in traditional folklores. In-depth scientific information relating to mechanisms of action, quality control, and safety profile will promote their extensive usage in cancer therapy. Metabolomics may be a more holistic strategy to gain valuable insights into the anticancer mechanisms of action of plants but this has remained largely unexplored. This review, therefore, presents the available metabolomics studies on the anticancer effects of herbal medicines commonly used in Africa and Asia. In addition, we present some scientifically understudied 'candidate plants' for cancer metabolomics studies and highlight the relevance of metabolomics in addressing other challenges facing the drug development of anticancer herbs. Finally, we discussed the challenges of using metabolomics to uncover the underlying mechanisms of potential anticancer herbs and the progress made in this regard.
癌细胞代谢组学为抗癌药物发现提供了许多机会。特别是中国、印度和非洲的植物群提供了多样化的抗癌治疗药物来源，这在传统民间传说中已有记载。深入的科学信息，包括作用机制、质量控制和安全性概况，将促进它们在癌症治疗中的广泛应用。代谢组学可能是一种更全面的策略，可以深入了解植物的抗癌作用机制，但这在很大程度上仍未得到探索。因此，本综述介绍了在非洲和亚洲常用草药的抗癌作用的现有代谢组学研究。此外，我们还介绍了一些在癌症代谢组学研究中科学研究较少的“候选植物”，并强调了代谢组学在解决抗癌草药药物开发面临的其他挑战方面的相关性。最后，我们讨论了使用代谢组学揭示潜在抗癌草药潜在作用机制的挑战，以及在这方面取得的进展。
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