Slamon D J, Boyle W J, Keith D E, Press M F, Golde D W, Souza L M
Department of Medicine, University of California, Los Angeles School of Medicine 90024.
J Virol. 1988 Mar;62(3):680-6. doi: 10.1128/JVI.62.3.680-686.1988.
Human T-cell leukemia virus type I is associated with human lymphoid malignancies. The p40xI protein encoded by the x gene of this virus is believed to play some role in virally mediated transformation. This gene is known to encode a transcriptional trans activator which previous studies have shown to be a nuclear protein. Further characterization of the intracellular kinetics of this protein showed that it migrated into the nucleus very soon after synthesis. Within the nucleus, p40xI was distributed almost equally between the nucleoplasm and the nuclear matrix. Given the proposed role of the nuclear matrix in RNA transcription, the association of p40xI with the matrix places it in an appropriate cellular compartment to exercise an effect on transcription.
人类I型T细胞白血病病毒与人类淋巴系统恶性肿瘤相关。该病毒x基因编码的p40xI蛋白被认为在病毒介导的转化过程中发挥一定作用。已知该基因编码一种转录反式激活因子，先前的研究表明它是一种核蛋白。对这种蛋白细胞内动力学的进一步研究表明，它在合成后很快就迁移到细胞核中。在细胞核内，p40xI几乎均匀地分布在核质和核基质之间。鉴于核基质在RNA转录中所起的作用，p40xI与核基质的结合使其处于一个合适的细胞区室中，从而能够对转录产生影响。
