Caprioglio Alberto, Fastuca Rosamaria, Zecca Piero Antonio, Beretta Matteo, Mangano Carlo, Piattelli Adriano, Macchi Aldo, Iezzi Giovanna
Department of Surgical and Morphological Sciences, University of Insubria, 21100 Varese, Italy.
Department of Medical, Surgical and Health Sciences, University of Messina, 98100 Messina, Italy.
Int J Mol Sci. 2017 Mar 11;18(3):615. doi: 10.3390/ijms18030615.
The present case report aimed to investigate immediate histologic changes in midpalatal suture in humans following rapid maxillary expansion compared to control. Three patients (mean age 8.3 +/- 0.9 years) were enrolled in the case report and underwent midpalatal suture biopsy. Two patients underwent treatment before biopsy. The third patient did not show transversal maxillary deficiency and was enrolled as a control. Biopsy samples of midpalatal suture at 7 (subject 1) and 30 days (subject 2) after maxillary expansion as well as of one control (subject 3) were collected and processed for histology. In the control (subject 3) inter-digitations at the palatal suture gap were observed. At 7 days (subject 1) mature bone with small marrow spaces and trabecular bone with the peculiar storiform appearance inside the soft tissue and collagen fibers running parallel only in the central part were present. At 30 days (subject 2), a greater number of newly-formed bone trabeculae with a perpendicular orientation to the long axis of the suture could be seen. At 30 days the fibrous component of bone tissue was less represented compared to the sample at 7 days. Data from the preliminary histological results showed that bone formation was observed in the gap after rapid maxillary expansion, although the healing process was still ongoing.
本病例报告旨在研究与对照组相比，快速上颌扩弓后人类腭中缝的即时组织学变化。三名患者（平均年龄8.3±0.9岁）被纳入该病例报告并接受腭中缝活检。两名患者在活检前接受了治疗。第三名患者未表现出上颌横向发育不足，被纳入作为对照组。收集了上颌扩弓后7天（受试者1）和30天（受试者2）的腭中缝活检样本以及一名对照组（受试者3）的样本，并进行组织学处理。在对照组（受试者3）中，观察到腭缝间隙处有指状交叉。在7天（受试者1）时，软组织内可见有小骨髓腔的成熟骨以及具有特殊板层状外观的小梁骨，胶原纤维仅在中央部分平行排列。在30天（受试者2）时，可以看到更多与缝的长轴垂直排列的新形成的骨小梁。与7天的样本相比，30天时骨组织的纤维成分减少。初步组织学结果的数据表明，尽管愈合过程仍在进行中，但在快速上颌扩弓后的间隙中观察到了骨形成。
