异种骨加猪胶原蛋白治疗临界尺寸骨缺损的骨愈合评估
Bone Healing Evaluation in Critical-Size Defects Treated With Xenogenous Bone Plus Porcine Collagen.
作者信息
Maciel Juceléia, Momesso Gustavo Antonio Correa, Ramalho-Ferreira Gabriel, Consolaro Renata Bianco, Perri de Carvalho Paulo Sérgio, Faverani Leonardo Perez, Farnezi Bassi Ana Paula
机构信息
*PhD Student, Department of Surgery and Integrated Clinic, Araçatuba Dental School, University Estadual Paulista (UNESP), Araçatuba, São Paulo, Brazil. †MSc Student, Department of Surgery and Integrated Clinic, Araçatuba Dental School, University Estadual Paulista (UNESP), Araçatuba, São Paulo, Brazil. ‡Assistant Professor, Department of Oral Pathology, Faculty Adamantinenses Integradas, Adamantina, Sao Paulo, Brazil. §Full Professor, Department of Surgery and Integrated Clinic, Araçatuba Dental School, University Estadual Paulista (UNESP), Araçatuba, São Paulo, Brazil; Department of Oral Pathology, Faculty Adamantinenses Integradas, Adamantina, Sao Paulo, Brazil. ¶Assistant Professor, Department of Surgery and Integrated Clinic, Araçatuba Dental School, University Estadual Paulista (UNESP), Araçatuba, São Paulo, Brazil.
出版信息
Implant Dent. 2017 Apr;26(2):296-302. doi: 10.1097/ID.0000000000000572.
PURPOSE
This study aimed to evaluate the osteoconductive features of Bio-Oss Collagen in large critical-size defects (8 mm).
MATERIALS AND METHODS
Thirty-six adult Wistar Albinus male adult rats were carried out a critical-size defect with a trephine bur of 8 mm in the calvaria. Groups were divided depending on the filling biomaterial as follows: group BO: Bio-Oss (n = 18); group BOC: Bio-Oss Collagen (n = 18). After 7, 30, and 60 days, 6 rats of each group were euthanized with anesthetic overdose. Specimens were laboratory processed for histomorphometric analysis. Histomorphometric data were statistically analyzed by analysis of variance and post-Tukey test (P < 0.05).
RESULTS
Statistical differences were found in new bone formation just in the intragroup comparison among periods after 7 and 60 postoperative days, indicating more new bone formation after 60 days (Tukey test, P = 0.029).
CONCLUSION
Under the limitation of this research, it could be concluded that Bio-Oss and Bio-Oss Collagen in this experimental model did not show osteoconductive features.
目的
本研究旨在评估Bio-Oss胶原在大型临界尺寸缺损（8毫米）中的骨传导特性。
材料与方法
对36只成年雄性Wistar白化大鼠颅骨进行8毫米环钻临界尺寸缺损。根据填充生物材料将组分为以下几组：BO组：Bio-Oss（n = 18）；BOC组：Bio-Oss胶原（n = 18）。在7天、30天和60天后，每组6只大鼠过量麻醉处死。标本经实验室处理进行组织形态计量分析。组织形态计量数据采用方差分析和事后Tukey检验进行统计学分析（P < 0.05）。
结果
仅在术后7天和60天后的组内时间段比较中发现新骨形成存在统计学差异，表明60天后新骨形成更多（Tukey检验，P = 0.029）。
结论
在本研究的局限性下，可以得出结论，在该实验模型中Bio-Oss和Bio-Oss胶原未表现出骨传导特性。
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