西班牙的生殖支原体：生殖器感染的患病率及对大环内酯类药物的耐药频率。
Mycoplasma genitalium in Spain: prevalence of genital infection and frequency of resistance to macrolides.
作者信息
Asenjo Alejandra, Kusters Johannes G, Severs Tim T, Alós Juan-Ignacio
机构信息
Servicio de Microbiología, Hospital Universitario de Getafe, Getafe, Madrid, Spain.
Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.
出版信息
Enferm Infecc Microbiol Clin (Engl Ed). 2018 Mar;36(3):169-171. doi: 10.1016/j.eimc.2017.01.006. Epub 2017 Mar 11.
INTRODUCTION
The aim of this study was to determine the prevalence of Mycoplasma genitalium infection and the resistance to macrolides within a general population in Madrid in 2015.
METHODS
We collected 359 urine samples from a general population with symptoms of sexually transmitted infections (STIs). All samples underwent a real-time PCR. For the detection of macrolide resistance, a 283bp fragment of region V of the 23S rRNA gene of M. genitalium was amplified and sequenced.
RESULTS
We found a prevalence of 3.34% of M. genitalium and a macrolide resistance rate of 20%. In males, the prevalence was 6.62% and in women 0.96%, being significantly higher in males.
CONCLUSIONS
The prevalence obtained shows that it is a pathogen to consider in our environment. These findings stress the need for routine testing of M. genitalium infections and would seem to suggest the advisability of resistance testing.
引言
本研究的目的是确定2015年马德里普通人群中生殖支原体感染的患病率以及对大环内酯类药物的耐药性。
方法
我们从有性传播感染（STIs）症状的普通人群中收集了359份尿液样本。所有样本均进行了实时聚合酶链反应（PCR）。为检测大环内酯类耐药性，对生殖支原体23S rRNA基因V区的一个283bp片段进行扩增和测序。
结果
我们发现生殖支原体的患病率为3.34%，大环内酯类耐药率为20%。男性患病率为6.62%，女性为0.96%，男性患病率显著更高。
结论
所获得的患病率表明它是我们环境中需要考虑的一种病原体。这些发现强调了对生殖支原体感染进行常规检测的必要性，似乎也表明了进行耐药性检测的可取性。
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