Khalil Ahmadaye Ibrahim, Bendahhou Karima, Mestaghanmi Houriya, Saile Rachid, Benider Abdellatif
Laboratoire de Physiopathologie et Génétique Moléculaire, Faculté des Sciences Ben M'Sik, Université Hassan II, Casablanca, Maroc.
Registre des Cancers de la Région du Grand Casablanca, Maroc.
Pan Afr Med J. 2016 Oct 27;25:121. doi: 10.11604/pamj.2016.25.121.9967. eCollection 2016.
Synchronous bilateral breast cancers (SBBC) are characterized by extensive clinical and morphological heterogeneity, with an frequency between 1.5 and 3.2%. Women treated for unilateral breast cancer are at higher risk of developing contralateral breast cancer. Screening and advances in breast imaging have improved detection rates of SBBC. Our study aims to analyze the epidemiological, clinical, histological and therapeutic features of bilateral breast cancer. We conducted a cross-sectional study of patients with breast cancer treated at the Mohammed VI Center over a two year period. Statistical analysis of the results was performed using R. software. 31 patients had SBBC, representing 2.4% of breast cancer cases in our Center. The average age was 47.8 ± 8.4 years, 22.6% of patients used oral contraceptives. A family history of breast cancer was observed in 22.6% of cases. The most common histological type was invasive ductal carcinoma (58.1%), SBR grade II and III were common (38.7%). Hormone receptors were positive for progesterone (38.7%) and for estrogen (41.9%). HER2 was overexpressed in 20.0% of cases. 29.0% of patients received hormonal therapy and 3.2% targeted therapies. Our study showed that bilateral breast cancer represents a small percentage of all breast cancers but have specific clinical features that help to differentiate it from unilateral breast cancer.
同步双侧乳腺癌（SBBC）具有广泛的临床和形态学异质性，发病率在1.5%至3.2%之间。接受单侧乳腺癌治疗的女性发生对侧乳腺癌的风险更高。乳腺成像的筛查和进展提高了SBBC的检出率。我们的研究旨在分析双侧乳腺癌的流行病学、临床、组织学和治疗特征。我们对在穆罕默德六世中心接受治疗的乳腺癌患者进行了为期两年的横断面研究。使用R软件对结果进行统计分析。31例患者患有SBBC，占我们中心乳腺癌病例的2.4%。平均年龄为47.8±8.4岁，22.6%的患者使用口服避孕药。22.6%的病例有乳腺癌家族史。最常见的组织学类型是浸润性导管癌（58.1%），SBR II级和III级常见（38.7%）。孕激素受体阳性率为38.7%，雌激素受体阳性率为41.9%。20.0%的病例HER2过表达。29.0%的患者接受了激素治疗，3.2%接受了靶向治疗。我们的研究表明，双侧乳腺癌在所有乳腺癌中占比小，但具有有助于将其与单侧乳腺癌区分开来的特定临床特征。
