尼日利亚人血清中的异源黄病毒感染增强抗体。

Heterologous flavivirus infection-enhancing antibodies in sera of Nigerians.

作者信息

Fagbami A, Halstead S B, Marchette N, Larsen K

机构信息

Department of Virology, College of Medicine, University of Ibadan, Nigeria.

出版信息

Am J Trop Med Hyg. 1988 Jan;38(1):205-7. doi: 10.4269/ajtmh.1988.38.205.

DOI:10.4269/ajtmh.1988.38.205

PMID:2829637

Abstract

Human sera collected from Nigerians were examined for plaque reduction neutralizing and infection-enhancing antibodies against dengue 2, yellow fever, and West Nile viruses. Neutralization tests showed that 17 of 19 sera contained flavivirus neutralizing antibody; 11 were positive to all 3 viruses, 5 to dengue and yellow fever, and 1 to dengue virus only. Two sera had no detectable neutralizing antibody to any of the flaviviruses. Enhancement assays showed that 17 flavivirus neutralizing antibody-positive sera contained infection-enhancing antibodies to dengue 2, and 16 had antibody to yellow fever. Although 11 sera were positive for West Nile neutralizing antibody, 17 enhanced this virus. Heterologous infection-enhancing antibody titers were lower than the homologous ones. Broadly reacting sera and those with high neutralizing antibody titers produced the highest infection-enhancing antibody titers.

摘要

对从尼日利亚人身上采集的人类血清进行检测，以寻找针对登革热2型、黄热病和西尼罗河病毒的蚀斑减少中和抗体及感染增强抗体。中和试验表明，19份血清中有17份含有黄病毒中和抗体；其中11份对所有3种病毒呈阳性，5份对登革热和黄热病呈阳性，1份仅对登革热病毒呈阳性。两份血清对任何黄病毒均未检测到中和抗体。增强试验表明，17份黄病毒中和抗体阳性血清含有针对登革热2型的感染增强抗体，16份含有针对黄热病的抗体。尽管11份血清对西尼罗河中和抗体呈阳性，但有17份增强了该病毒的感染。异源感染增强抗体滴度低于同源抗体滴度。广泛反应的血清和中和抗体滴度高的血清产生的感染增强抗体滴度最高。