Reyes Zenaida Soriano, Al-Mulaabed Sharef Waadallah, Bataclan Flordeliz, Montemayor Cheryl, Ganesh Anuradha, Al-Zuhaibi Sanaa, Al-Waili Huda, Al-Wahibi Fatma
Department of Child Health, Sultan Qaboos University Hospital, Muscat, Oman.
Department of Ophthalmology, Sultan Qaboos University Hospital, Muscat, Oman.
Oman J Ophthalmol. 2017 Jan-Apr;10(1):26-32. doi: 10.4103/ojo.OJO_234_2014.
The purpose of this study is to determine the incidence of retinopathy of prematurity (ROP) and the maternal/neonatal risk factors at a tertiary care hospital in Oman, compared to other countries.
A retrospective analysis of premature neonates born with gestational age (GA) 24-32 weeks at Sultan Qaboos University Hospital, Oman, from January 2007 to December 2010. Maternal and neonatal in-hospital course was retrieved. The incidence of ROP was reported. Risk factors analyses were performed using univariate and multivariate statistics.
A total of 171 neonates (57% males, 43% females) were included for analysis. The incidence of ROP (any stage) was 69/171 (40.4%). Infants with ROP had significantly lower GA (27.7±2 weeks) compared to non-ROP group (30.2±1.7 weeks), < 0.001),P < 0.001) and significantly lower birth weight (BW) (948 ± 242 g in ROP group vs. 1348 ± 283 g in non-ROP group;P < 0.001). Other significant risk factors associated with ROP were: small for GA, respiratory distress syndrome, requirement for ventilation, duration of ventilation or oxygen therapy, bronchopulmonary dysplasia, hyperglycemia, late onset sepsis (clinical or proven), necrotizing enterocolitis, patent ductus arteriosus, seizures, and number of blood transfusions. There was no significant difference in maternal characteristics between the ROP and non-ROP groups except that mothers of infants with ROP were found to be significantly younger. Logistic regression analysis revealed early GA, low BW, duration of Oxygen therapy, and late-onset clinical or proven sepsis as independent risk factors.
ROP is still commonly encountered in neonatal practice in Oman and other countries. Early GA, low BW, and prolonged oxygen therapy continue to be the main risk factors associated with the occurrence of ROP in our setting. In addition, an important preventable risk factor identified in our cohort includes clinical or proven late-onset sepsis.
本研究旨在确定阿曼一家三级护理医院中早产儿视网膜病变（ROP）的发病率以及母体/新生儿危险因素，并与其他国家进行比较。
对2007年1月至2010年12月在阿曼苏丹卡布斯大学医院出生的孕周为24 - 32周的早产儿进行回顾性分析。收集母体和新生儿的住院病程。报告ROP的发病率。使用单变量和多变量统计进行危险因素分析。
共纳入171例新生儿（57%为男性，43%为女性）进行分析。ROP（任何阶段）的发病率为69/171（40.4%）。与无ROP组相比，ROP患儿的孕周显著更低（27.7±2周对30.2±1.7周，P<0.001），出生体重（BW）也显著更低（ROP组为948±242克，无ROP组为1348±283克；P<0.001）。与ROP相关的其他显著危险因素包括：小于胎龄儿、呼吸窘迫综合征、通气需求、通气或氧疗持续时间、支气管肺发育不良、高血糖、晚发性败血症（临床诊断或确诊）、坏死性小肠结肠炎、动脉导管未闭、惊厥以及输血次数。ROP组和无ROP组的母体特征无显著差异，只是ROP患儿的母亲明显更年轻。逻辑回归分析显示，孕周早、出生体重低、氧疗持续时间以及晚发性临床诊断或确诊败血症是独立危险因素。
在阿曼及其他国家的新生儿实践中，ROP仍然常见。孕周早、出生体重低和氧疗时间延长仍是我们研究中与ROP发生相关的主要危险因素。此外,我们队列中确定的一个重要可预防危险因素包括临床诊断或确诊的晚发性败血症。
