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指纹分析及菌株ST309的鉴定:墨西哥城儿童菌血症分离人群中一种潜在的高风险克隆株

Fingerprint Analysis and Identification of Strains ST309 as a Potential High Risk Clone in a Population Isolated from Children with Bacteremia in Mexico City.

作者信息

Morales-Espinosa Rosario, Delgado Gabriela, Espinosa Luis F, Isselo Dassaev, Méndez José L, Rodriguez Cristina, Miranda Guadalupe, Cravioto Alejandro

机构信息

Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México Mexico City, Mexico.

Servicio de Pediatría, Hospital Regional 36 San Alejandro, IMSS Puebla, Mexico.

出版信息

Front Microbiol. 2017 Mar 1;8:313. doi: 10.3389/fmicb.2017.00313. eCollection 2017.

Abstract

is an opportunistic pathogen and is associated with nosocomial infections. Its ability to thrive in a broad range of environments is due to a large and diverse genome of which its accessory genome is part. The objective of this study was to characterize strains isolated from children who developed bacteremia, using pulse-field gel electrophoresis, and in terms of its genomic islands, virulence genes, multilocus sequence type, and antimicrobial susceptibility. Our results showed that strains presented the seven virulence genes: 1, and , a type IV pilin alleles (TFP) group I or II. Additionally, we detected a novel pilin and accessory gene, expanding the number of TFP alleles to group VI. All strains presented the PAPI-2 Island and the majority were + and + genotype. Ten percent of the strains were multi-drug resistant phenotype, 18% extensively drug-resistant, 68% moderately resistant and only 3% were susceptible to all the antimicrobial tested. The most prevalent acquired β-Lactamase was KPC. We identified a group of ST309 strains, as a potential high risk clone. Our finding also showed that the strains isolated from patients with bacteremia have important virulence factors involved in colonization and dissemination as: a TFP group I or II; the presence of the gene within the PAPI-2 island and the presence of the gene.

摘要

是一种机会致病菌,与医院感染有关。它能够在广泛的环境中生存,这归因于其庞大且多样的基因组,其辅助基因组是其中一部分。本研究的目的是使用脉冲场凝胶电泳,并从基因组岛、毒力基因、多位点序列类型和抗菌药物敏感性方面,对从发生菌血症的儿童中分离出的菌株进行特征分析。我们的结果表明,菌株呈现出七个毒力基因:1、和,IV型菌毛等位基因(TFP)I组或II组。此外,我们检测到一个新的菌毛和辅助基因,将TFP等位基因数量扩展到VI组。所有菌株均呈现PAPI - 2岛,大多数为+和+基因型。10%的菌株为多重耐药表型,18%为广泛耐药,68%为中度耐药,只有3%对所有测试抗菌药物敏感。最常见的获得性β - 内酰胺酶是KPC。我们鉴定出一组ST309菌株,作为潜在的高风险克隆。我们的研究结果还表明,从菌血症患者中分离出的菌株具有参与定植和传播的重要毒力因子,如:TFP I组或II组;PAPI - 2岛内存在基因以及存在基因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7642/5331068/7cedd9d2b402/fmicb-08-00313-g0001.jpg

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