血压正常且血糖正常的中国中老年人群中非高密度脂蛋白胆固醇与颈动脉粥样硬化的关系
Relationship between non-high-density lipoprotein cholesterol and carotid atherosclerosis in normotensive and euglycemic Chinese middle-aged and elderly adults.
作者信息
Ma Hui, Lin Huandong, Hu Yu, Li Xiaoming, He Wanyuan, Jin Xuejuan, Gao Jian, Zhao Naiqing, Pan Boshen, Gao Xin
机构信息
Department of Geriatrics, Zhong Shan Hospital, Fudan University, Shanghai, 200032, China.
Department of Endocrinology and Metabolism, Zhong Shan Hospital, Fudan University, Shanghai, 200032, China.
出版信息
Lipids Health Dis. 2017 Mar 16;16(1):55. doi: 10.1186/s12944-017-0451-4.
BACKGROUND
We investigate whether non-high-density lipoprotein cholesterol (non-HDL-C) provides a better estimate of cardiovascular risk than other lipid profiles in normotensive and euglycemic middle-aged and elderly adults.
METHODS
A total of 512 males and 958 females were enrolled from the Changfeng Study. A standard interview, anthropometric measurements and laboratory analyses were performed for each participant. Bilateral carotid intima-media thicknesses (CIMTs) were measured using ultrasonography, and the presence of carotid plaques was assessed.
RESULTS
The mean values of non-HDL-C were 3.4 ± 0.8 mmol/l and 3.6 ± 0.9 mmol/l for male and female subjects, respectively. Compared with female subjects with non-HDL-C in the first quartile, female subjects with non-HDL-C in the fourth quartile had 1.317-fold increased risks for carotid plaques after adjusting for conventional cardiovascular disease (CVD) risk factors and increasing quartiles of all lipid levels. Non-HDL-C was positively associated with the CIMT after adjusting for CVD risk factors in female subjects (β = 0.062, P = 0.034).
CONCLUSIONS
These results suggest that non-HDL-C is independently associated with carotid atherosclerosis in normotensive and euglycemic females.
背景
我们研究在血压正常且血糖正常的中老年成年人中，非高密度脂蛋白胆固醇（non-HDL-C）是否比其他血脂指标能更好地评估心血管风险。
方法
从长风研究中招募了512名男性和958名女性。对每位参与者进行标准访谈、人体测量和实验室分析。使用超声测量双侧颈动脉内膜中层厚度（CIMT），并评估颈动脉斑块的存在情况。
结果
男性和女性受试者的non-HDL-C平均值分别为3.4±0.8 mmol/l和3.6±0.9 mmol/l。在调整传统心血管疾病（CVD）危险因素和所有血脂水平的四分位数增加后，与处于non-HDL-C第一四分位数的女性受试者相比，处于第四四分位数的女性受试者患颈动脉斑块的风险增加了1.317倍。在调整女性受试者的CVD危险因素后，non-HDL-C与CIMT呈正相关（β = 0.062，P = 0.034）。
结论
这些结果表明，在血压正常且血糖正常的女性中，non-HDL-C与颈动脉粥样硬化独立相关。
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