Kemmner Wolfgang, Schaller H Chica
Max-Planck-Institut für Medizinische Forschung, Abteilung Biophysik und Zoophysiologie, Universität Heidelberg, Jahnstr. 29, 6900, Heidelberg, Germany.
Wilehm Roux Arch Dev Biol. 1981 Jul;190(4):191-196. doi: 10.1007/BF00848302.
The mutantreg-16 is deficient in head regeneration and abnormal in size regulation. The gastric region becomes twice as long as that of normal animals before the first bud is produced. Both mutant characteristics are due to changes in head-specific morphogen concentrations.Reg-16 contains twice as much head inhibitor and only half as much head activator in its head as normal animals. This leads to a higher level of free head inhibitor in the whole animal resulting on one hand in a greater distance of buds from the head, and on the other hand in a total blockage of release of head activator and head inhibitor which would be necessary to initiate head regeneration.
突变体reg-16在头部再生方面存在缺陷，并且在大小调节上异常。在产生第一个芽之前，胃部区域的长度变为正常动物的两倍。这两个突变特征均归因于头部特异性形态发生素浓度的变化。与正常动物相比，Reg-16头部中的头部抑制剂含量是其两倍，而头部激活剂含量仅为其一半。这导致整个动物体内游离头部抑制剂的水平升高，一方面使得芽与头部之间的距离更远，另一方面导致启动头部再生所需的头部激活剂和头部抑制剂的释放完全受阻。
