Lehmann Ruth, Dietrich Ursula, Jiménez F, Campos-Ortega J A
Institut für Biologie III, Schäzlestraße 1, 7800, Freiburg i. Br., Germany.
Wilehm Roux Arch Dev Biol. 1981 Jul;190(4):226-229. doi: 10.1007/BF00848307.
Embryonic lethal mutations at the Notch locus are known to produce a conspicuous central nervous system hypertrophy accompanied by a hypotrophy of the epidermal sheath. We have studied several zygotic mutants belonging to four different autosomal complementation groups which produce the same phenotype. The embryonic development of the new mutants, as well as that of Notch, consists of an initial enlargement of the neurogenic region at the expenses of epidermal cell precursors. The possibility is discussed that these five loci are involved in the determination of neural and epidermal cell precursors.
已知Notch基因座的胚胎致死突变会导致明显的中枢神经系统肥大，并伴有表皮鞘萎缩。我们研究了属于四个不同常染色体互补群的几个合子突变体，它们产生相同的表型。新突变体以及Notch的胚胎发育都包括以表皮细胞前体为代价的神经源区域的初始扩大。讨论了这五个基因座参与神经和表皮细胞前体确定的可能性。
