Adler S P
Children's Medical Center, Department of Pediatrics, Medical College of Virginia, Richmond.
J Pediatr. 1988 Mar;112(3):366-72. doi: 10.1016/s0022-3476(88)80314-7.
This 26-month prospective study monitored 104 children from one day care center (DCC), and their families, for cytomegalovirus (CMV) infections. Among the children, 14 different strains of CMV were identified by restriction endonuclease analysis of the viral DNA of isolates. Three of these strains infected 44 DCC children and apparently were transmitted within the DCC environment. Only children younger than 3 years of age acquired the DCC-associated CMV strains. Of 75 seronegative children in this age group, 34 acquired DCC-associated CMV strains, and four were infected with unique strains. Among 23 children older than 3 years of age, none acquired the DCC-associated strains, although six were infected with unique strains. Of 18 seronegative mothers, six acquired CMV infections within 3 to 7 months after their children became infected; the strains were identical to those isolated from their children and were DCC associated. Four fathers, three seropositive mothers, and two caretakers also shed DCC-associated strains of CMV. None of the 31 mothers whose children were not infected shed CMV. There was no apparent CMV-associated morbidity. These results prove the frequent transmission of CMV within the DCC environment and from DCC children to their parents. They further suggest that caretakers do acquire CMV from DCC children.
这项为期26个月的前瞻性研究对来自一家日托中心（DCC）的104名儿童及其家庭进行了巨细胞病毒（CMV）感染监测。在这些儿童中，通过对分离株病毒DNA进行限制性内切酶分析，鉴定出了14种不同的CMV毒株。其中三种毒株感染了44名日托中心儿童，显然是在日托中心环境中传播的。只有3岁以下的儿童感染了与日托中心相关的CMV毒株。在这个年龄组的75名血清阴性儿童中，34名感染了与日托中心相关的CMV毒株，4名感染了独特的毒株。在23名3岁以上的儿童中，没有人感染与日托中心相关的毒株，尽管有6人感染了独特的毒株。在18名血清阴性的母亲中，有6名在其子女感染后3至7个月内感染了CMV；毒株与从其子女身上分离出的毒株相同，且与日托中心相关。4名父亲、3名血清阳性母亲和2名看护人也排出了与日托中心相关的CMV毒株。31名子女未感染的母亲均未排出CMV。没有明显的与CMV相关的发病情况。这些结果证明了CMV在日托中心环境中以及从日托中心儿童传播给其父母的频繁发生。它们进一步表明，看护人确实会从日托中心儿童那里感染CMV。
