Namkung Ho, Kim Sun-Hong, Sawa Akira
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Trends Neurosci. 2017 Apr;40(4):200-207. doi: 10.1016/j.tins.2017.02.002. Epub 2017 Mar 15.
Supported by recent human neuroimaging studies, the insula is re-emerging as an important brain area not only in the physiological understanding of the brain, but also in pathological contexts in clinical research. In this opinion article, we briefly introduce the anatomical and histological features of the human insula. We then summarize the physiological functions of the insula and underscore its pathological roles in psychiatric and neurological disorders that have long been underestimated. We finally propose possible strategies through which the role of the insula may be further understood for both basic and clinical neuroscience.
在最近的人类神经影像学研究的支持下，脑岛不仅在大脑的生理理解方面，而且在临床研究的病理背景中，正重新成为一个重要的脑区。在这篇观点文章中，我们简要介绍了人类脑岛的解剖和组织学特征。然后，我们总结了脑岛的生理功能，并强调了其在长期以来被低估的精神和神经疾病中的病理作用。最后，我们提出了一些可能的策略，通过这些策略，脑岛的作用在基础和临床神经科学中都可能得到进一步的理解。
