McBride Alison A
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Biol Chem. 2017 Jul 26;398(8):919-927. doi: 10.1515/hsz-2017-0113.
Animal and human papillomaviruses (HPVs) replicate persistently in specific types of stratified epithelia of their host. After the initial infection, the viral genome replicates at low levels in the dividing cells of the epithelium, and these cells form a reservoir of infection that can last for decades. When the infected cells differentiate, viral genomes replicate to high levels to form progeny virus that is released from the surface of the epithelium. This complex life cycle requires several different modes of viral DNA replication, but papillomaviruses are masters at hijacking key cellular processes to facilitate their own reproduction.
动物和人乳头瘤病毒（HPV）在其宿主的特定类型复层上皮中持续复制。初次感染后，病毒基因组在上皮的分裂细胞中低水平复制，这些细胞形成可持续数十年的感染库。当受感染细胞分化时，病毒基因组高水平复制以形成从上皮表面释放的子代病毒。这种复杂的生命周期需要几种不同的病毒DNA复制模式，但乳头瘤病毒善于劫持关键的细胞过程以促进自身繁殖。
