Moody Cary
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Viruses. 2017 Sep 19;9(9):261. doi: 10.3390/v9090261.
Human papillomaviruses (HPV) are the causative agents of cervical cancer and are also associated with other genital malignancies, as well as an increasing number of head and neck cancers. HPVs have evolved their life cycle to contend with the different cell states found in the stratified epithelium. Initial infection and viral genome maintenance occurs in the proliferating basal cells of the stratified epithelium, where cellular replication machinery is abundant. However, the productive phase of the viral life cycle, including productive replication, late gene expression and virion production, occurs upon epithelial differentiation, in cells that normally exit the cell cycle. This review outlines how HPV interfaces with specific cellular signaling pathways and factors to provide a replication-competent environment in differentiating cells.
人乳头瘤病毒（HPV）是宫颈癌的致病因子，还与其他生殖器恶性肿瘤以及越来越多的头颈癌有关。HPV已经进化了其生命周期，以应对复层上皮中发现的不同细胞状态。初始感染和病毒基因组维持发生在复层上皮的增殖基底细胞中，那里细胞复制机制丰富。然而，病毒生命周期的生产阶段，包括生产性复制、晚期基因表达和病毒粒子产生，发生在上皮分化时，即在正常退出细胞周期的细胞中。本综述概述了HPV如何与特定细胞信号通路和因子相互作用，以在分化细胞中提供一个具有复制能力的环境。
