溶血磷脂酰胆碱-酰基C16:0与男性棕色脂肪组织活性相关。
LysoPC-acyl C16:0 is associated with brown adipose tissue activity in men.
作者信息
Boon Mariëtte R, Bakker Leontine E H, Prehn Cornelia, Adamski Jerzy, Vosselman Maarten J, Jazet Ingrid M, Arias-Bouda Lenka M Pereira, van Lichtenbelt Wouter D Marken, van Dijk Ko Willems, Rensen Patrick C N, Mook-Kanamori Dennis O
机构信息
Department of Medicine, Division of Endocrinology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.
出版信息
Metabolomics. 2017;13(5):48. doi: 10.1007/s11306-017-1185-z. Epub 2017 Mar 3.
INTRODUCTION
Brown adipose tissue (BAT) recently emerged as a potential therapeutic target in the treatment of obesity and associated disorders due to its fat-burning capacity. The current gold standard in assessing BAT activity is [F]FDG PET-CT scan, which has severe limitations including radiation exposure, being expensive, and being labor-intensive. Therefore, indirect markers are needed of human BAT activity and volume.
OBJECTIVE
We aimed to identify metabolites in serum that are associated with BAT volume and activity in men.
METHODS
We assessed 163 metabolites in fasted serum of a cohort of twenty-two healthy lean men (age 24.1 (21.7-26.6) years, BMI 22.1 (20.5-23.4) kg/m) who subsequently underwent a cold-induced [F]FDG PET-CT scan to assess BAT volume and activity. In addition, we included three replication cohorts consisting of in total thirty-seven healthy lean men that were similar with respect to age and BMI compared to the discovery cohort.
RESULTS
After correction for multiple testing, fasting concentrations of lysophosphatidylcholine-acyl (LysoPC-acyl) C16:1, LysoPC-acyl C16:0 and phosphatidylcholine-diacyl C32:1 showed strong positive correlations with BAT volume (β= 116 (85-148) mL, R = 0.81, p = 4.6 × 10 β = 79 (93-119) mL, R = 0.57, p = 5.9 × 10 and β= 91 (40-141) mL, R = 0.52, p = 1.0 × 10, respectively) as well as with BAT activity (β= 0.20 (0.11-0.29) g/mL, R = 0.59, p = 1.9 × 10; β = 0.15 (0.06-0.23) g/mL, R = 0.47, p = 2.0 × 10 and β= 0.13 (0.01-0.25) g/mL, R = 0.28, p = 0.04, respectively). When tested in three independent replication cohorts (total n = 37), the association remained significant between LysoPC-acyl C16:0 and BAT activity in a pooled analysis (β= 0.15 (0.07-0.23) g/mL, R = 0.08, p = 4.2 × 10).
CONCLUSIONS
LysoPC-acyl C16:0 is associated with BAT activity in men. Since BAT is regarded as a promising tool in the battle against obesity and related disorders, the identification of such a noninvasive marker is highly relevant.
引言
棕色脂肪组织（BAT）因其脂肪燃烧能力，最近成为治疗肥胖及相关疾病的潜在治疗靶点。评估BAT活性的当前金标准是[F]FDG PET-CT扫描，其存在严重局限性，包括辐射暴露、成本高昂以及劳动强度大。因此，需要人类BAT活性和体积的间接标志物。
目的
我们旨在识别与男性BAT体积和活性相关的血清代谢物。
方法
我们评估了一组22名健康瘦男性（年龄24.1（21.7 - 26.6）岁，BMI 22.1（20.5 - 23.4）kg/m²）空腹血清中的163种代谢物，这些男性随后接受了冷诱导的[F]FDG PET-CT扫描以评估BAT体积和活性。此外，我们纳入了三个重复队列，总共37名健康瘦男性，他们在年龄和BMI方面与发现队列相似。
结果
在进行多重检验校正后，溶血磷脂酰胆碱 - 酰基（LysoPC - acyl）C16:1、LysoPC - acyl C16:0和磷脂酰胆碱 - 二酰基C32:1的空腹浓度与BAT体积呈强正相关（β = 116（85 - 148）mL，R = 0.81，p = 4.6×10⁻⁹；β = 79（93 - 119）mL，R = 0.57，p = 5.9×10⁻⁵；β = 91（40 - 141）mL，R = 0.52，p = 1.0×10⁻⁴，分别），以及与BAT活性呈强正相关（β = 0.20（0.11 - 0.29）g/mL，R = 0.59，p = 1.9×10⁻⁵；β = 0.15（0.06 - 0.23）g/mL，R = 0.47，p = 2.0×10⁻³；β = 0.13（0.01 - 0.25）g/mL，R = 0.28，p = 0.04，分别）。在三个独立的重复队列（共n = 37）中进行测试时，在汇总分析中，LysoPC - acyl C16:0与BAT活性之间的关联仍然显著（β = 0.15（0.07 - 0.23）g/mL，R = 0.08，p = 4.2×10⁻²）。
结论
LysoPC - acyl C16:0与男性的BAT活性相关。由于BAT被视为对抗肥胖及相关疾病的有前景的工具，识别这样一种非侵入性标志物具有高度相关性。
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