Ahmadipour A, Sharififar F, Najafi A, Atashbar J, Karami-Mohajeri S
Pharmaceutics Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran.
J Med Life. 2015;8(Spec Iss 4):270-274.
The analgesic paracetamol causes a potentially fatal, centrilobular hepatic necrosis when taken in misuse and overdose. This research aimed to evaluate the protective effects of methanolic extract of Zataria Multiflora Boiss (Z. Multiflora) against hepatic damage induced by paracetamol-induced hepatotoxicity in male Wistar rats. for this purpose, paracetamol was administrated orally at a dose of 2 g/ kg body weight (b.w.)/ day on the seventh day after the oral administration of a methanolic extract of Z. Multiflora at doses of 100 mg/ kg, 200 mg/ kg and 400 mg/ kg b.w. The lipid peroxidation level and activities of liver aminotransferases and enzymes contributing to the oxidative damage were measured in serum, and a histopathological examination of liver sections was also performed. The results showed that Z. Multiflora reduced the activity of aminotransferases in rats treated with paracetamol. This extract also inhibited lipid peroxidation and protein carbonylation by an increase in the activity of the antioxidant enzyme and the elevation of glutathione content of the liver. These effects are related to the antioxidant compounds of Z. Multiflora. The methanolic extract of this herb exhibits protective effects against paracetamol-induced hepatotoxicity.
镇痛药物对乙酰氨基酚误服或过量服用时会导致潜在致命的小叶中心性肝坏死。本研究旨在评估百里香（Zataria Multiflora Boiss，Z. Multiflora）甲醇提取物对雄性Wistar大鼠对乙酰氨基酚诱导的肝毒性所致肝损伤的保护作用。为此，在口服剂量为100 mg/kg、200 mg/kg和400 mg/kg体重的Z. Multiflora甲醇提取物后的第7天，以2 g/kg体重/天的剂量口服给予对乙酰氨基酚。测定血清中脂质过氧化水平、肝脏氨基转移酶活性以及导致氧化损伤的酶活性，并对肝脏切片进行组织病理学检查。结果表明，Z. Multiflora降低了用对乙酰氨基酚处理的大鼠的氨基转移酶活性。该提取物还通过增加抗氧化酶活性和提高肝脏谷胱甘肽含量来抑制脂质过氧化和蛋白质羰基化。这些作用与Z. Multiflora的抗氧化化合物有关。这种草药的甲醇提取物对乙酰氨基酚诱导的肝毒性具有保护作用。
