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本文引用的文献

1
S100A9-induced release of interleukin (IL)-6 and IL-8 through toll-like receptor 4 (TLR4) in human periodontal ligament cells.S100A9通过人牙周膜细胞中的Toll样受体4（TLR4）诱导白细胞介素（IL）-6和IL-8的释放。
Mol Immunol. 2015 Oct;67(2 Pt B):223-32. doi: 10.1016/j.molimm.2015.05.014. Epub 2015 May 31.
2
The pro-apoptotic and pro-inflammatory effects of calprotectin on human periodontal ligament cells.钙卫蛋白对人牙周膜细胞的促凋亡和促炎作用。
PLoS One. 2014 Oct 22;9(10):e110421. doi: 10.1371/journal.pone.0110421. eCollection 2014.
3
Alarmin S100A8/S100A9 as a biomarker for molecular imaging of local inflammatory activity.警报素S100A8/S100A9作为局部炎症活动分子成像的生物标志物。
Nat Commun. 2014 Aug 6;5:4593. doi: 10.1038/ncomms5593.
4
Toll-like receptor 4-mediated hyper-responsiveness of gingival epithelial cells to lipopolysaccharide in high-glucose environments.Toll样受体4介导的高糖环境中牙龈上皮细胞对脂多糖的高反应性。
J Periodontol. 2014 Nov;85(11):1620-8. doi: 10.1902/jop.2014.140087. Epub 2014 May 30.
5
S100A8 and S100A9: DAMPs at the crossroads between innate immunity, traditional risk factors, and cardiovascular disease.S100A8 和 S100A9：固有免疫、传统危险因素和心血管疾病之间的 DAMPs 交汇点。
Mediators Inflamm. 2013;2013:828354. doi: 10.1155/2013/828354. Epub 2013 Dec 22.
6
The role of Toll-like receptor 2 and 4 in gingival tissues of chronic periodontitis subjects with type 2 diabetes.Toll样受体2和4在2型糖尿病慢性牙周炎患者牙龈组织中的作用
J Periodontal Res. 2014 Jun;49(3):346-54. doi: 10.1111/jre.12112. Epub 2013 Jul 12.
7
Periodontal disease and type 1 diabetes mellitus: associations with glycemic control and complications: an Indian perspective.牙周病与1型糖尿病：与血糖控制及并发症的关联：印度视角
Diabetes Metab Syndr. 2013 Apr-Jun;7(2):61-3. doi: 10.1016/j.dsx.2013.03.001. Epub 2013 Mar 26.
8
Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosis.高血糖促进骨髓生成，并损害动脉粥样硬化的消退。
Cell Metab. 2013 May 7;17(5):695-708. doi: 10.1016/j.cmet.2013.04.001.
9
The distribution and expression of S100A8 and S100A9 in gingival epithelium of mice.S100A8 和 S100A9 在小鼠牙龈上皮中的分布与表达。
J Periodontal Res. 2013 Apr;48(2):235-42. doi: 10.1111/jre.12000. Epub 2012 Sep 7.
10
[Expression of glucose transporter-1 and insulin receptor alpha1 in osteoblast obtained from diabetic rats' mandibles].[糖尿病大鼠下颌骨成骨细胞中葡萄糖转运蛋白-1和胰岛素受体α1的表达]
Hua Xi Kou Qiang Yi Xue Za Zhi. 2011 Aug;29(4):348-50, 354.

[S100A9在糖尿病大鼠牙周组织中的表达及作用]

[Expression and effect of S100A9 in the periodontium of diabetic rats].

作者信息

Wenhua Sun, Guoqing Chen, Weidong Tian

机构信息

College of Life Science, Sichuan University, Chengdu 610065, China;State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China;National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu 610041, China.

State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China;National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu 610041, China.

出版信息

Hua Xi Kou Qiang Yi Xue Za Zhi. 2016 Aug 1;34(4):419-424. doi: 10.7518/hxkq.2016.04.020.

DOI:10.7518/hxkq.2016.04.020
PMID:28317364
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7030020/
Abstract

OBJECTIVE

The study seeks to investigate the expression of S100A9 and its potential role in periodontal diseases induced by diabetes.

METHODS

A diabetic SD rat model was established through intraperitoneal injection of streptozotocin (STZ). Hematoxylin-eosin (HE) staining was performed to study the structure of the periodontium of diabetic rats. Using immunohistochemical staining, the distribution of S100A9 expression was detected in the periodontium of diabetic rats. Ex-pressions of Toll-like receptor 4 (TLR4) (ligands of S100A9) and p-P65/nuclear factor κB (NF-κB) were also measured.

RESULTS

The trabecular structure of alveolar bone was sparser, and lamina dura was disappeared in diabetic rats. Obviously higher expressions of S100A9 were observed in the periodontal ligament, alveolar bone, and gingival epithelial of diabetic rats than in the control rats. TLR4 expressions in the periodontal ligament, alveolar bone and gingival epithelial of the diabetic rats were also higher as compared to the control rats. p-P65 expression was not detected in the control rats, but was detected in the periodontal ligament and alveolar bone of the diabetic rats.

CONCLUSIONS: Periodontium lesions in diabetes mellitus may be induced by the activation of TLR4 and NF-κB signaling pathway meditated by S100A9. 
.

摘要

目的

本研究旨在探讨S100A9的表达及其在糖尿病所致牙周疾病中的潜在作用。

方法

通过腹腔注射链脲佐菌素（STZ）建立糖尿病SD大鼠模型。采用苏木精-伊红（HE）染色观察糖尿病大鼠牙周组织的结构。运用免疫组织化学染色检测糖尿病大鼠牙周组织中S100A9表达的分布情况。同时检测Toll样受体4（TLR4）（S100A9的配体）和p-P65/核因子κB（NF-κB）的表达。

结果

糖尿病大鼠牙槽骨小梁结构稀疏，硬骨板消失。糖尿病大鼠牙周膜、牙槽骨和牙龈上皮中S100A9的表达明显高于对照组大鼠。糖尿病大鼠牙周膜、牙槽骨和牙龈上皮中TLR4的表达也高于对照组大鼠。对照组大鼠未检测到p-P65表达，而糖尿病大鼠的牙周膜和牙槽骨中检测到p-P65表达。

结论

糖尿病中的牙周组织病变可能由S100A9介导的TLR4和NF-κB信号通路激活所致。