Kim Tae Su, Kim Eun Hui, Chung Jong Woo
1 Department of Otolaryngology, School of Medicine, Kangwon National University , Chuncheon, Korea.
2 Department of Health Screening and Promotion Center, Asan Medical Center, University of Ulsan College of Medicine , Seoul, Korea.
Metab Syndr Relat Disord. 2017 Jun;15(5):240-245. doi: 10.1089/met.2016.0153. Epub 2017 Mar 20.
Although several observational studies showed a relationship between various conditions of metabolic syndrome (MetS) and hearing threshold, there are no studies about longitudinal audiometric results related MetS. The aim of this study was to investigate the association between MetS and age-related hearing impairment (ARHI) through a large, average 5-year longitudinal follow-up, clinical comparative analysis.
We recruited 1381 women older than 50 years who were enrolled in 2007 and reevaluated in 2012. They had normal or symmetrical sensorineural hearing loss. For the evaluation of the independent impact of MetS on hearing, multivariate analysis was used.
The average follow-up period was 5.0 ± 0.2 years. Subjects with MetS had higher hearing thresholds than subjects without MetS. The loss in high-frequency hearing (≥2000 Hz) progressed more rapidly in women with MetS over a 5-year period.
Our analysis using longitudinal and large data revealed that MetS is associated with ARHI in women 50 years and older. High-frequency hearing loss tended to be greater in women with MetS than in those without MetS at the 5-year follow-up. Therefore, older women with MetS should be followed up closely for hearing evaluation.
尽管多项观察性研究表明各种代谢综合征（MetS）状况与听力阈值之间存在关联，但尚无关于与MetS相关的纵向听力测定结果的研究。本研究的目的是通过一项大规模、平均为期5年的纵向随访临床对比分析，调查MetS与年龄相关性听力减退（ARHI）之间的关联。
我们招募了1381名50岁以上的女性，她们于2007年入组并于2012年进行重新评估。她们有正常或对称性感音神经性听力损失。为评估MetS对听力的独立影响，采用了多变量分析。
平均随访期为5.0±0.2年。患有MetS的受试者听力阈值高于未患MetS的受试者。在5年期间，患有MetS的女性高频听力（≥2000Hz）损失进展更快。
我们使用纵向和大量数据进行的分析表明，MetS与50岁及以上女性的ARHI相关。在5年随访中，患有MetS的女性高频听力损失往往比未患MetS的女性更大。因此，患有MetS的老年女性应密切随访以进行听力评估。
