由AKT8鼠逆转录病毒诱导的胸腺淋巴瘤
Thymic lymphoma induction by the AKT8 murine retrovirus.
作者信息
Staal S P, Hartley J W
机构信息
Johns Hopkins Oncology Center, Baltimore, Maryland 21205.
出版信息
J Exp Med. 1988 Mar 1;167(3):1259-64. doi: 10.1084/jem.167.3.1259.
Abstract
The directly transforming murine retrovirus, AKT8, was isolated from a spontaneous AKR thymoma and carries the cell-derived viral oncogene, akt. We have now shown that this virus produces thymic lymphomas after inoculation of susceptible mouse strains. The presence of the AKT8 genome in the DNA of the virus-induced tumors was demonstrated by Southern blotting using an akt-specific probe. These results establish the in vivo pathogenicity of the AKT8 virus and its akt oncogene, and imply a potential role for the cellular akt proto-oncogene in tumor development.
摘要
直接转化型鼠逆转录病毒AKT8是从自发的AKR胸腺瘤中分离出来的，它携带细胞衍生的病毒癌基因akt。我们现已表明，接种易感小鼠品系后，这种病毒会引发胸腺淋巴瘤。使用akt特异性探针通过Southern印迹法证实了病毒诱导肿瘤的DNA中存在AKT8基因组。这些结果证实了AKT8病毒及其akt癌基因在体内的致病性，并暗示细胞akt原癌基因在肿瘤发生中可能发挥作用。
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