微生物群与啮齿动物模型的可重复性
Microbiota and reproducibility of rodent models.
作者信息
Franklin Craig L, Ericsson Aaron C
机构信息
Department of Veterinary Pathobiology at the University of Missouri in Columbia, Missouri.
出版信息
Lab Anim (NY). 2017 Mar 22;46(4):114-122. doi: 10.1038/laban.1222.
Abstract
The gut microbiota (GM) plays a critical role in human health and disease. Likewise, it is becoming increasingly evident that changes or disruptions to the GM can have significant effects on animal models and their expressed phenotypes, adding a complex and important variable into basic research and preclinical studies. In this article, we review some of the most common sources of GM variability in rodent models, and discuss measures to address this variability for improved reproducibility.
摘要
肠道微生物群（GM）在人类健康和疾病中起着关键作用。同样，越来越明显的是，GM的变化或破坏会对动物模型及其表达的表型产生重大影响，这给基础研究和临床前研究增加了一个复杂而重要的变量。在本文中，我们回顾了啮齿动物模型中GM变异性的一些最常见来源，并讨论了应对这种变异性以提高可重复性的措施。
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