Hassan Fadi, Trebinjac Suad, Murrell William D, Maffulli Nicola
Good Hope Hospital, Heart of England NHS Foundation Trust, Birmingham, B75 7RR, UK.
Dubai Physiotherapy & Rehabilitation Center, Al Garhoud Private Hospital, Al Garhoud, United Arab Emirates.
Br Med Bull. 2017 Jun 1;122(1):91-108. doi: 10.1093/bmb/ldx006.
Osteoarthritis (OA) often leads to symptoms such as pain, stiffness and decreased function. OA is treated with a wide range of modalities, both conservatively and surgically. Prolotherapy has been used to treat various musculoskeletal problems and has shown some promise.
Searches of the electronic databases, PubMed, ISI web of science, PEDro and SPORTDiscus, were conducted for all Level 1-4 studies published from inception through to December 2016.
Ten studies were evaluated and results show significant improvement in scores for pain, function and range of motion, both in the short term and long term. Patient satisfaction was also high in these patients (82%).
Meta-analysis was not possible due to heterogeneity of outcome measures and populations.
Moderate evidence suggests that prolotherapy is safe and can help achieve significant symptomatic control in individuals with OA.
Future research should focus on larger sample size, standardization of treatment protocol and basic science evidence.
骨关节炎（OA）常导致疼痛、僵硬和功能下降等症状。OA的治疗方式多种多样，包括保守治疗和手术治疗。注射疗法已被用于治疗各种肌肉骨骼问题，并显示出一定的前景。
对电子数据库PubMed、科学网ISI、PEDro和SPORTDiscus进行检索，纳入从数据库建立至2016年12月发表的所有1-4级研究。
评估了10项研究，结果显示，无论是短期还是长期，疼痛、功能和活动范围评分均有显著改善。这些患者的满意度也较高（82%）。
由于结局指标和研究人群的异质性，无法进行荟萃分析。
中等证据表明，注射疗法是安全的，并且可以帮助显著控制OA患者的症状。
未来的研究应集中在更大的样本量、治疗方案的标准化和基础科学证据方面。
