Katashima Carlos K, Silva Vagner R, Gomes Tatyanne L, Pichard Claude, Pimentel Gustavo D
Campinas University, Brazil.
Clinical and Sports Nutrition Research Laboratory (Labince), School of Nutrition (FANUT), Federal University of Goias (UFG), Goiânia, GO, Brazil.
Obes Rev. 2017 Jun;18(6):700-711. doi: 10.1111/obr.12523. Epub 2017 Mar 23.
This systematic review aimed at addressing the ursolic acid actions as an adjunctive treatment of the obesity-mediated metabolic abnormalities. To explore our aims, we used the literature search including clinical and animal studies using the Medline and Google Scholar (up to December 2015). Out of 63 screened studies, 17 presented eligibility criteria, such as the use of ursolic acid on adiposity, energy expenditure and skeletal muscle mass in mice and humans. In the literature, we found that several physiological and molecular mechanisms are implicated in the effects of ursolic acid on obesity, energy expenditure, hepatic steatosis, skeletal muscle mass loss and physical fitness, such as (1) increase of thermogenesis by modulation adipocyte transcription factors, activation of 5' adenosine monophosphate-activated protein kinase and overexpression of the uncoupling protein 1 thermogenic marker; (2) enhancement of skeletal muscle mass by activation in bloodstream growth hormone and insulin-like growth factor-1 concentrations secretion, as well as in the activation of mammalian target of rapamycin and inhibition of ring-finger protein-1; and (3) improvement of physical fitness by skeletal muscle proliferator-activated receptor gamma co-activator alpha and sirtuin 1 expression. Therefore, supplementation with ursolic acid may be an adjunctive therapy for prevention and treatment of obesity-mediated and muscle mass-mediated metabolic consequences.
本系统评价旨在探讨熊果酸作为肥胖介导的代谢异常辅助治疗手段的作用。为探究我们的目标，我们进行了文献检索，包括使用Medline和谷歌学术（截至2015年12月）检索临床和动物研究。在63项筛选出的研究中，17项呈现了纳入标准，如在小鼠和人类中使用熊果酸对肥胖、能量消耗和骨骼肌质量的影响。在文献中，我们发现熊果酸对肥胖、能量消耗、肝脂肪变性、骨骼肌质量损失和体能的影响涉及多种生理和分子机制，例如：（1）通过调节脂肪细胞转录因子增加产热，激活5'-腺苷单磷酸激活的蛋白激酶并使解偶联蛋白1产热标志物过表达；（2）通过激活血液中生长激素和胰岛素样生长因子-1浓度分泌，以及激活雷帕霉素靶蛋白并抑制环指蛋白-1来增强骨骼肌质量；（3）通过骨骼肌增殖激活受体γ共激活因子α和沉默调节蛋白1表达来改善体能。因此，补充熊果酸可能是预防和治疗肥胖介导及肌肉质量介导的代谢后果的辅助疗法。
