水相合成氧化铁纳米粒子及其复合材料用于癌症的诊断和治疗。

Aqueous-phase synthesis of iron oxide nanoparticles and composites for cancer diagnosis and therapy.

机构信息

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, PR China.

College of Materials Science and Engineering, Donghua University, Shanghai 201620, PR China.

出版信息

Adv Colloid Interface Sci. 2017 Nov;249:374-385. doi: 10.1016/j.cis.2017.02.009. Epub 2017 Mar 14.

DOI:10.1016/j.cis.2017.02.009

PMID:28335985

Abstract

The design and development of multifunctional nanoplatforms for biomedical applications still remains to be challenging. This review reports the recent advances in aqueous-phase synthesis of iron oxide nanoparticles (FeO NPs) and their composites for magnetic resonance (MR) imaging and photothermal therapy of cancer. Water dispersible and colloidally stable FeO NPs synthesized via controlled coprecipitation route, hydrothermal route and mild reduction route are introduced. Some of key strategies to improve the r relaxivity of FeO NPs and to enhance their uptake by cancer cells are discussed in detail. These aqueous-phase synthetic methods can also be applied to prepare FeO NP-based composites for dual-mode molecular imaging applications. More interestingly, aqueous-phase synthesized FeO NPs are able to be fabricated as multifunctional theranostic agents for multi-mode imaging and photothermal therapy of cancer. This review will provide some meaningful information for the design and development of various FeO NP-based multifunctional nanoplatforms for cancer diagnosis and therapy.

摘要

多功能纳米平台在生物医学领域的设计与开发仍然具有挑战性。本综述报告了铁氧化物纳米粒子（FeO NPs）及其复合材料在癌症的磁共振成像（MR）和光热治疗中的最新进展。本文介绍了通过控制共沉淀法、水热法和温和还原法合成的在水中可分散和胶体稳定的 FeO NPs。详细讨论了一些提高 FeO NPs 的 r1 弛豫率和增强其被癌细胞摄取的关键策略。这些水相合成方法也可用于制备用于双模分子成像应用的 FeO NP 基复合材料。更有趣的是，水相合成的 FeO NPs 可以被制成多功能治疗剂，用于癌症的多模式成像和光热治疗。本综述将为设计和开发用于癌症诊断和治疗的各种基于 FeO NP 的多功能纳米平台提供有意义的信息。