补充益生菌对食物过敏小鼠肠道微生物群影响的探究
Exploration of the effect of probiotics supplementation on intestinal microbiota of food allergic mice.
作者信息
Yang Bo, Xiao Liang, Liu Sheng, Liu Xiaoyu, Luo Yan, Ji Qiongmei, Yang Pingchang, Liu Zhigang
机构信息
Institute of Allergy and Immunology, School of Medicine, Shenzhen UniversityShenzhen 518060, China; Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen UniversityShenzhen 518060, China.
BGI Shenzhen Shenzhen, China.
出版信息
Am J Transl Res. 2017 Feb 15;9(2):376-385. eCollection 2017.
Abstract
Environmental factor-induced alterations in intestinal microbiota have been demonstrated to be associated with increasing prevalence of food allergy. However, it is not clear to what extent oral administration of probiotics can affect gut microbiota composition, thus inhibiting food allergy development. Using ovalbumin (OVA)-sensitized murine model, it was demonstrated that probiotics ameliorated allergic symptoms, including reducing OVA specific-IgE, and -IgG1 levels in the serum, Th2 cytokines release in spleen, and occurrence of diarrhea. Moreover, 16S rRNA analysis showed that the probiotics-mediated protection was conferred by an enrichment of and . The present study supports the theory that probiotics can treat food allergy by modulating specific genera of the gut microbiota.
摘要
环境因素引起的肠道微生物群改变已被证明与食物过敏患病率增加有关。然而，口服益生菌在多大程度上能够影响肠道微生物群组成从而抑制食物过敏的发展尚不清楚。利用卵清蛋白（OVA）致敏的小鼠模型，研究表明益生菌可改善过敏症状，包括降低血清中OVA特异性IgE和IgG1水平、脾脏中Th2细胞因子的释放以及腹泻的发生。此外，16S rRNA分析表明，益生菌介导的保护作用是通过富集 和 实现的。本研究支持了益生菌可通过调节肠道微生物群的特定属来治疗食物过敏的理论。
相似文献
1
Exploration of the effect of probiotics supplementation on intestinal microbiota of food allergic mice.补充益生菌对食物过敏小鼠肠道微生物群影响的探究
Am J Transl Res. 2017 Feb 15;9(2):376-385. eCollection 2017.
2
Herbal Formula-3 ameliorates OVA-induced food allergy in mice may via modulating the gut microbiota.中药复方3可能通过调节肠道微生物群改善卵清蛋白诱导的小鼠食物过敏。
Am J Transl Res. 2019 Sep 15;11(9):5812-5823. eCollection 2019.
3
Probio-M9 alleviates OVA-sensitized food allergy through modulating gut microbiota and its metabolism.益生菌M9通过调节肠道微生物群及其代谢来缓解卵清蛋白致敏的食物过敏。
Food Funct. 2023 Dec 11;14(24):10784-10795. doi: 10.1039/d3fo03321j.
4
Development of Gut Microbiota in a Mouse Model of Ovalbumin-induced Allergic Diarrhea under Sub-barrier System.在亚屏障系统下卵清蛋白诱导的过敏性腹泻小鼠模型中肠道微生物群的发育
Asian-Australas J Anim Sci. 2013 Apr;26(4):545-51. doi: 10.5713/ajas.2012.12502.
5
Probiotic Interventions Alleviate Food Allergy Symptoms Correlated With Cesarean Section: A Murine Model.益生菌干预减轻与剖宫产相关的食物过敏症状：一种小鼠模型。
Front Immunol. 2021 Sep 28;12:741371. doi: 10.3389/fimmu.2021.741371. eCollection 2021.
6
Protective effect of CGMCC313-2 on ovalbumin-induced airway asthma and β-lactoglobulin-induced intestinal food allergy mouse models.CGMCC313-2对卵清蛋白诱导的气道哮喘和β-乳球蛋白诱导的肠道食物过敏小鼠模型的保护作用。
World J Gastroenterol. 2017 Mar 28;23(12):2149-2158. doi: 10.3748/wjg.v23.i12.2149.
7
Intermittent fasting protects against food allergy in a murine model regulating gut microbiota.间歇性禁食通过调节肠道微生物群预防小鼠食物过敏
Front Immunol. 2023 May 9;14:1167562. doi: 10.3389/fimmu.2023.1167562. eCollection 2023.
8
9
Curcumin Ingestion Inhibits Mastocytosis and Suppresses Intestinal Anaphylaxis in a Murine Model of Food Allergy.在食物过敏小鼠模型中，摄入姜黄素可抑制肥大细胞增多症并抑制肠道过敏反应。
PLoS One. 2015 Jul 6;10(7):e0132467. doi: 10.1371/journal.pone.0132467. eCollection 2015.
10
Yogurt-sourced probiotic bacteria alleviate shrimp tropomyosin-induced allergic mucosal disorders, potentially through microbiota and metabolism modifications.酸奶源益生菌可通过调节肠道微生物群和代谢缓解虾肌球蛋白诱导的过敏黏膜病变。
Allergol Int. 2019 Oct;68(4):506-514. doi: 10.1016/j.alit.2019.05.013. Epub 2019 Jun 28.
引用本文的文献
1
Relationship between Infant Feeding and the Microbiome: Implications for Allergies and Food Intolerances.婴儿喂养与微生物群的关系：对过敏和食物不耐受的影响。
Children (Basel). 2024 Aug 22;11(8):1030. doi: 10.3390/children11081030.
2
Targeting Food Allergy with Probiotics.益生菌靶向治疗食物过敏。
Adv Exp Med Biol. 2024;1449:79-93. doi: 10.1007/978-3-031-58572-2_5.
3
Evaluation of Neuro-Hormonal Dynamics after the Administration of Probiotic Microbial Strains in a Murine Model of Hyperthyroidism.评价益生菌菌株对甲状腺功能亢进症小鼠神经激素动态的影响。
Nutrients. 2024 Apr 6;16(7):1077. doi: 10.3390/nu16071077.
4
Update on In Vitro Diagnostic Tools and Treatments for Food Allergies.食物过敏的体外诊断工具和治疗方法的最新进展。
Nutrients. 2023 Aug 26;15(17):3744. doi: 10.3390/nu15173744.
5
Effects of high oleic acid peanuts on mice's liver and adipose tissue metabolic parameters and gut microbiota composition.高油酸花生对小鼠肝脏和脂肪组织代谢参数及肠道微生物群组成的影响。
Front Nutr. 2023 Jul 27;10:1205377. doi: 10.3389/fnut.2023.1205377. eCollection 2023.
6
Advances in the Study of Probiotics for Immunomodulation and Intervention in Food Allergy.益生菌用于免疫调节及干预食物过敏的研究进展
Molecules. 2023 Jan 27;28(3):1242. doi: 10.3390/molecules28031242.
7
Intranasal administration of Acinetobacter lwoffii in a murine model of asthma induces IL-6-mediated protection associated with cecal microbiota changes.鼻腔内给予鲁氏不动杆菌在哮喘小鼠模型中诱导与盲肠微生物群变化相关的 IL-6 介导的保护作用。
Allergy. 2023 May;78(5):1245-1257. doi: 10.1111/all.15606. Epub 2022 Dec 11.
8
Research Progress on the Correlation between the Intestinal Microbiota and Food Allergy.肠道微生物群与食物过敏相关性的研究进展
Foods. 2022 Sep 19;11(18):2913. doi: 10.3390/foods11182913.
9
Strain Alleviates Gluten-Induced Food Allergy and Regulates Gut Microbiota in Mice.菌株缓解了由谷蛋白引起的食物过敏，并调节了小鼠的肠道微生物群。
Front Cell Infect Microbiol. 2022 Apr 22;12:845142. doi: 10.3389/fcimb.2022.845142. eCollection 2022.
10
The Gluten-Free Diet for Celiac Disease and Beyond.无麸质饮食：不仅仅针对乳糜泻
Nutrients. 2021 Nov 9;13(11):3993. doi: 10.3390/nu13113993.
本文引用的文献
1
Characterization of Der f 29, a new allergen from dermatophagoides farinae.粉尘螨新变应原Der f 29的特性分析
Am J Transl Res. 2015 Jul 15;7(7):1303-13. eCollection 2015.
2
Understanding probiotics' role in allergic children: the clue of gut microbiota profiling.了解益生菌在过敏儿童中的作用：肠道微生物群分析的线索
Curr Opin Allergy Clin Immunol. 2015 Oct;15(5):495-503. doi: 10.1097/ACI.0000000000000203.
3
The role of the commensal microbiota in the regulation of tolerance to dietary allergens.共生微生物群在调节对饮食过敏原耐受性中的作用。
Curr Opin Allergy Clin Immunol. 2015 Jun;15(3):243-9. doi: 10.1097/ACI.0000000000000157.
4
Intestinal microbiota in health and disease: role of bifidobacteria in gut homeostasis.健康与疾病中的肠道微生物群：双歧杆菌在肠道稳态中的作用。
World J Gastroenterol. 2014 Nov 7;20(41):15163-76. doi: 10.3748/wjg.v20.i41.15163.
5
Commensal bacteria protect against food allergen sensitization.共生细菌可预防食物过敏原致敏。
Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13145-50. doi: 10.1073/pnas.1412008111. Epub 2014 Aug 25.
6
An improved nonparametric lower bound of species richness via a modified good-turing frequency formula.通过改进的古德-图灵频率公式得到的物种丰富度的改进非参数下界。
Biometrics. 2014 Sep;70(3):671-82. doi: 10.1111/biom.12200. Epub 2014 Jun 19.
7
Effects of Lactobacillus rhamnosus on allergic march model by suppressing Th2, Th17, and TSLP responses via CD4(+)CD25(+)Foxp3(+) Tregs.鼠李糖乳杆菌通过调节 CD4(+)CD25(+)Foxp3(+)T regs 抑制 Th2、Th17 和 TSLP 应答对过敏进程模型的影响。
Clin Immunol. 2014 Jul;153(1):178-86. doi: 10.1016/j.clim.2014.04.008. Epub 2014 Apr 24.
8
Maternal and postnatal dietary probiotic supplementation enhances splenic regulatory T helper cell population and reduces ovalbumin allergen-induced hypersensitivity responses in mice.孕期及产后补充膳食益生菌可增加小鼠脾脏调节性辅助性T细胞数量，并降低卵清蛋白过敏原诱导的超敏反应。
Immunobiology. 2014 May;219(5):367-76. doi: 10.1016/j.imbio.2014.01.003. Epub 2014 Jan 18.
9
Plaque bacterial microbiome diversity in children younger than 30 months with or without caries prior to eruption of second primary molars.30个月以下乳牙第二乳磨牙萌出前有或无龋齿儿童的牙菌斑细菌微生物群多样性
PLoS One. 2014 Feb 28;9(2):e89269. doi: 10.1371/journal.pone.0089269. eCollection 2014.
10
Clinical efficacy and mechanism of probiotics in allergic diseases.益生菌在过敏性疾病中的临床疗效及作用机制
Korean J Pediatr. 2013 Sep;56(9):369-76. doi: 10.3345/kjp.2013.56.9.369. Epub 2013 Sep 30.
Zotero 插件