Yang Bo, Xiao Liang, Liu Sheng, Liu Xiaoyu, Luo Yan, Ji Qiongmei, Yang Pingchang, Liu Zhigang
Institute of Allergy and Immunology, School of Medicine, Shenzhen UniversityShenzhen 518060, China; Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen UniversityShenzhen 518060, China.
BGI Shenzhen Shenzhen, China.
Am J Transl Res. 2017 Feb 15;9(2):376-385. eCollection 2017.
Environmental factor-induced alterations in intestinal microbiota have been demonstrated to be associated with increasing prevalence of food allergy. However, it is not clear to what extent oral administration of probiotics can affect gut microbiota composition, thus inhibiting food allergy development. Using ovalbumin (OVA)-sensitized murine model, it was demonstrated that probiotics ameliorated allergic symptoms, including reducing OVA specific-IgE, and -IgG1 levels in the serum, Th2 cytokines release in spleen, and occurrence of diarrhea. Moreover, 16S rRNA analysis showed that the probiotics-mediated protection was conferred by an enrichment of and . The present study supports the theory that probiotics can treat food allergy by modulating specific genera of the gut microbiota.
环境因素引起的肠道微生物群改变已被证明与食物过敏患病率增加有关。然而，口服益生菌在多大程度上能够影响肠道微生物群组成从而抑制食物过敏的发展尚不清楚。利用卵清蛋白（OVA）致敏的小鼠模型，研究表明益生菌可改善过敏症状，包括降低血清中OVA特异性IgE和IgG1水平、脾脏中Th2细胞因子的释放以及腹泻的发生。此外，16S rRNA分析表明，益生菌介导的保护作用是通过富集 和 实现的。本研究支持了益生菌可通过调节肠道微生物群的特定属来治疗食物过敏的理论。
