College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
College of Information and Electrical Engineering, China Agricultural University, Beijing, China.
Front Cell Infect Microbiol. 2022 Apr 22;12:845142. doi: 10.3389/fcimb.2022.845142. eCollection 2022.
Wheat flour, the most important source of food globally, is also one of the most common causative agents of food allergy. Wheat gluten protein, which accounts for 80% of the total wheat protein, is a major determinant of important wheat-related disorders. In this study, the effects of against gluten-induced allergy were investigated in a mouse model. The oral administration of attenuated clinical and intestinal allergic responses in allergic mice. Further results showed that regulated Th1/Th2 immune balance toward Th1 polarization, which subsequently induced a reduction in gluten-specific IgE production. We also found that modulated gut microbiota homeostasis by balancing the / ratio and increasing bacterial diversity and the abundance of butyrate-producing bacteria. Specifically, the abundance of and is positively correlated with concentrations of gluten-specific IgE and may act as a fecal biomarker for diagnosis. The evidence for the role of in alleviating gluten-induced allergic responses sheds light on the application of in treating wheat allergy.
小麦面粉是全球最重要的食物来源之一，也是最常见的食物过敏原之一。小麦面筋蛋白占总小麦蛋白的 80%，是与小麦相关的重要疾病的主要决定因素。在这项研究中，研究了 对小麦诱导的过敏的抑制作用在小鼠模型中。口服 可减轻过敏小鼠的临床和肠道过敏反应。进一步的结果表明， 调节 Th1/Th2 免疫平衡向 Th1 极化，从而导致减少了对 gluten-specific IgE 的产生。我们还发现， 通过平衡 / 比例和增加细菌多样性以及丁酸产生菌的丰度来调节肠道微生物组平衡。具体而言， 和 的丰度与 gluten-specific IgE 的浓度呈正相关，可能作为诊断的粪便生物标志物。 缓解小麦诱导的过敏反应的作用的证据为 在治疗小麦过敏中的应用提供了思路。
