Brüssow H, Werchau H, Liedtke W, Lerner L, Mietens C, Sidoti J, Sotek J
Nestlé Research Center, Lausanne, Switzerland.
J Infect Dis. 1988 May;157(5):1014-22. doi: 10.1093/infdis/157.5.1014.
We studied the prevalence of antibody to rotavirus in 386 serum samples obtained from different age-groups of infants in Bochum, West Germany. Cord sera mirrored the IgG titer and serotype specificity of the corresponding maternal sera. IgG antibody prevalence decreased with age, reached a minimum between four and 12 months, and increased thereafter. IgM antibodies appeared first in the eight- to 12-month age-group, and IgM prevalence remained high thereafter. The serum level of IgA was low in all age-groups. Significant prevalence increases with increasing age were observed for neutralizing antibodies to rotavirus serotypes 1 and 3. Antibodies to serotype 4 had not reached adult level at 2.5 y of age. Prevalence of antibodies to serotype 2 was low in all age-groups. The percentage of monospecific sera neutralizing only one serotype was high in young infants eight to 12 months of age and decreased significantly with increasing age.
我们研究了从西德波鸿不同年龄组婴儿获取的386份血清样本中轮状病毒抗体的流行情况。脐血血清反映了相应母血血清的IgG滴度和血清型特异性。IgG抗体流行率随年龄增长而下降，在4至12个月时降至最低，此后又有所上升。IgM抗体首先出现在8至12个月龄组，此后IgM流行率一直很高。所有年龄组的IgA血清水平都很低。观察到针对轮状病毒1型和3型的中和抗体流行率随年龄增长显著增加。4型抗体在2.5岁时未达到成人水平。所有年龄组中2型抗体的流行率都很低。在8至12个月龄的幼儿中，仅中和一种血清型的单特异性血清百分比很高，且随年龄增长显著下降。
