南美洲和中欧儿童中针对9型轮状病毒WI61血清中和抗体的流行情况。
Prevalence of serum neutralizing antibody to serotype 9 rotavirus WI61 in children from South America and central Europe.
作者信息
Brüssow H, Clark H F, Sidoti J
机构信息
Nestlé Research Centre, Nestec Ltd., Lausanne, Switzerland.
出版信息
J Clin Microbiol. 1991 Jan;29(1):208-11. doi: 10.1128/jcm.29.1.208-211.1991.
Abstract
Neutralizing serum antibody to serotype 9 rotavirus WI61 was detected in 41% of 870 Ecuadorian children and 26% of 140 German children. In both areas an age-related prevalence increase was observed. We identified 11 serum samples from Ecuadorian children which neutralized exclusively serotype 9 rotavirus. Thirteen of 71 (18%) German children hospitalized with serologically defined primary rotavirus gastroenteritis showed a seroconversion to serotype 9 rotavirus; however, in 10 of these 13 patients, the infecting serotype could be identified as serotype 1, 3, or 4. Furthermore, all 13 patients showed fourfold increases in titer to at least one further serotype.
摘要
在870名厄瓜多尔儿童中，41%检测到针对9型轮状病毒WI61的中和血清抗体；在140名德国儿童中，26%检测到该抗体。在这两个地区，均观察到与年龄相关的患病率上升。我们从厄瓜多尔儿童中鉴定出11份血清样本，这些样本仅能中和9型轮状病毒。在71名因血清学确诊的原发性轮状病毒肠胃炎住院的德国儿童中，13名（18%）出现了针对9型轮状病毒的血清转化；然而，在这13名患者中的10名中，感染血清型可鉴定为1型、3型或4型。此外，所有13名患者针对至少一种其他血清型的滴度均出现了四倍增加。
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