Centre for Exercise and Nutrition, Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria 3000, Australia.
Cold Spring Harb Perspect Med. 2017 Oct 3;7(10):a029884. doi: 10.1101/cshperspect.a029884.
The application of global "-omics" technologies to exercise has introduced new opportunities to map the complexity and interconnectedness of biological networks underlying the tissue-specific responses and systemic health benefits of exercise. This review will introduce major research tracks and recent advancements in this emerging field, as well as critical gaps in understanding the orchestration of molecular exercise dynamics that will benefit from unbiased omics investigations. Furthermore, significant research hurdles that need to be overcome to effectively fill these gaps related to data collection, computation, interpretation, and integration across omics applications will be discussed. Collectively, a cross-disciplinary physiological and omics-based systems approach will lead to discovery of a wealth of novel exercise-regulated targets for future mechanistic validation. This frontier in exercise biology will aid the development of personalized therapeutic strategies to improve athletic performance and human health through precision exercise medicine.
“组学”技术在运动领域的应用为绘制运动对组织特异性反应和整体健康益处的分子机制网络的复杂性和关联性提供了新的机会。本综述将介绍这一新兴领域的主要研究轨迹和最新进展，以及在理解分子运动动力学协调方面存在的关键空白，这些空白将受益于无偏组学研究。此外，还将讨论在有效填补与数据收集、计算、解释和跨组学应用整合相关的空白方面需要克服的重大研究障碍。总的来说，跨学科的生理和基于组学的系统方法将有助于发现大量新的运动调节靶点，为未来的机制验证提供依据。运动生物学的这一前沿领域将有助于通过精准运动医学制定个性化治疗策略，以提高运动表现和改善人类健康。
