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一名患有系统性硬化症和继发性干燥综合征的患者因腮腺炎导致菌血症。

bacteraemia due to parotitis in a patient with systemic sclerosis and secondary Sjögren's syndrome.

作者信息

Yii Irene Yuen Lin, Tan Jamie Bee Xian, Fong Warren Weng Seng

机构信息

Department of Rheumatology and Immunology, Singapore General Hospital , Singapore.

Department of Pathology, Singapore General Hospital, Singapore.

出版信息

JMM Case Rep. 2016 Oct 31;3(5):e005068. doi: 10.1099/jmmcr.0.005068. eCollection 2016 Oct.

Abstract

INTRODUCTION

Invasive pneumococcal disease is an uncommon and notifiable disease in Singapore. It is often associated with significant morbidity and mortality. We report a rare case of invasive pneumococcal bacteraemia due to parotitis in a patient with systemic sclerosis and secondary Sjögren's syndrome. We also present a retrospective review of bacteraemia cases in Singapore General Hospital from January 2011 to April 2016.

CASE PRESENTATION

A 59-year-old Malay lady with a history of systemic sclerosis with secondary Sjögren's syndrome presented with fever and left parotid gland swelling. Clinical examination revealed poor salivary pooling and left parotid swelling without fluctuance. Ultrasound of the left parotid gland confirmed acute parotitis without evidence of abscess or sialolithiasis. Blood cultures were positive for . She was diagnosed to have invasive pneumococcal bacteraemia secondary to acute parotitis, and treated with intravenous benzylpenicillin with clearance of bacteraemia after 3 days. Upon discharge, her antibiotics were changed to intravenous ceftriaxone to facilitate outpatient parenteral antibiotic therapy for another 2 weeks. She responded favourably to antibiotics at follow-up, with no complications from the bacteraemia. A review of the microbiological records of the Singapore General Hospital revealed 116 cases of pneumococcal bacteraemia, most (80.3 %) of which were due to pneumonia. None were due to parotitis.

CONCLUSION

parotitis and subsequent bacteraemia is rare. Prompt recognition of the disease and appropriate use of antibiotics are important. This case highlights that close communication between healthcare workers (microbiologist, rheumatologist and infectious disease specialist) is essential in ensuring good clinical outcomes in patients with a potentially fatal disease.

摘要

引言

侵袭性肺炎球菌病在新加坡是一种罕见的法定报告疾病。它常与严重的发病率和死亡率相关。我们报告了一例患有系统性硬化症和继发性干燥综合征的患者因腮腺炎导致侵袭性肺炎球菌菌血症的罕见病例。我们还对2011年1月至2016年4月新加坡总医院的菌血症病例进行了回顾性分析。

病例介绍

一名59岁患有系统性硬化症并继发干燥综合征的马来女性患者出现发热和左侧腮腺肿胀。临床检查发现唾液积聚不良且左侧腮腺肿胀但无波动感。左侧腮腺超声检查确诊为急性腮腺炎,无脓肿或涎石病迹象。血培养结果为[此处原文缺失具体细菌名称]阳性。她被诊断为急性腮腺炎继发侵袭性肺炎球菌菌血症,并接受静脉注射苄星青霉素治疗,3天后菌血症得以清除。出院时,她的抗生素改为静脉注射头孢曲松,以便进行另外2周的门诊胃肠外抗生素治疗。随访时她对抗生素反应良好,菌血症未引发并发症。对新加坡总医院微生物学记录的回顾显示,有116例肺炎球菌菌血症病例,其中大多数(80.3%)是由肺炎引起的。无一例是由腮腺炎引起的。

结论

腮腺炎及随后的菌血症很罕见。及时识别该疾病并合理使用抗生素很重要。该病例强调了医护人员(微生物学家、风湿病学家和传染病专家)之间密切沟通对于确保患有潜在致命疾病的患者获得良好临床结果至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f069/5343148/ec55af6e54ca/jmmcr-03-5068-f001.jpg

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