抗人类免疫缺陷病毒药物3'-叠氮基-3'-脱氧胸腺嘧啶核苷可抑制爱泼斯坦-巴尔病毒的复制。
Anti-human immunodeficiency virus agent 3'-azido-3'-deoxythymidine inhibits replication of Epstein-Barr virus.
作者信息
Lin J C, Zhang Z X, Smith M C, Biron K, Pagano J S
机构信息
Lineberger Cancer Research Center, School of Medicine, University of North Carolina, Chapel Hill 27514.
出版信息
Antimicrob Agents Chemother. 1988 Feb;32(2):265-7. doi: 10.1128/AAC.32.2.265.
Abstract
We show that the anti-human immunodeficiency virus agent, 3'-azido-3'-deoxythymidine (AZT), which suppresses infectivity and cytopathic effects of human immunodeficiency virus, also effectively inhibits Epstein-Barr virus (EBV) DNA replication. However, AZT has no effect on four other human herpesviruses: cytomegalovirus, varicella-zoster virus, and herpes simplex virus types 1 and 2. The combination of acyclovir and AZT, while it is not synergistic, has an additive effect against EBV replication. AZT may prove to be a useful drug for treatment of coinfections with human immunodeficiency virus and EBV.
摘要
我们发现，抗人类免疫缺陷病毒药物3'-叠氮-3'-脱氧胸苷（AZT）可抑制人类免疫缺陷病毒的感染性和细胞病变效应，它也能有效抑制爱泼斯坦-巴尔病毒（EBV）的DNA复制。然而，AZT对其他四种人类疱疹病毒没有作用：巨细胞病毒、水痘-带状疱疹病毒以及1型和2型单纯疱疹病毒。阿昔洛韦和AZT联合使用时，虽无协同作用，但对EBV复制有相加效应。AZT可能被证明是治疗人类免疫缺陷病毒和EBV合并感染的一种有用药物。
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