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本文引用的文献

1
Adhesion phenotype manifests an altered metabolic profile favoring glycolysis.黏附表型表现出有利于糖酵解的代谢谱改变。
Fertil Steril. 2016 Jun;105(6):1628-1637.e1. doi: 10.1016/j.fertnstert.2016.02.009. Epub 2016 Feb 23.
2
Endoplasmic Reticulum Ca(2+) Handling and Apoptotic Resistance in Tumor-Derived Endothelial Colony Forming Cells.内质网Ca(2+)处理与肿瘤来源的内皮集落形成细胞中的凋亡抗性
J Cell Biochem. 2016 Oct;117(10):2260-71. doi: 10.1002/jcb.25524. Epub 2016 Mar 14.
3
Episode of Familial Mediterranean Fever-Related Peritonitis in the Second Trimester of Pregnancy Followed by Acute Cholecystitis: Dilemmas and Pitfalls.妊娠中期家族性地中海热相关腹膜炎并发急性胆囊炎:困境与陷阱
Am J Case Rep. 2016 Feb 24;17:115-9. doi: 10.12659/ajcr.896017.
4
Quantitative Histomorphometry of the Healthy Peritoneum.健康腹膜的定量组织形态计量学
Sci Rep. 2016 Feb 19;6:21344. doi: 10.1038/srep21344.
5
Use of Modified Polysaccharide 4DryField (®) PH for Adhesion Prevention and Hemostasis in Gynecological Surgery: A Two-Center Observational Study by Second-Look Laparoscopy.改良多糖4DryField(®)PH在妇科手术中预防粘连和止血的应用:一项通过二次腹腔镜检查的双中心观察性研究。
Biomed Res Int. 2016;2016:3029264. doi: 10.1155/2016/3029264. Epub 2016 Jan 24.
6
Injectable pullulan hydrogel for the prevention of postoperative tissue adhesion.可注射普鲁兰水凝胶预防术后组织粘连。
Int J Biol Macromol. 2016 Jun;87:155-62. doi: 10.1016/j.ijbiomac.2016.02.026. Epub 2016 Feb 12.
7
P-glycoprotein Mediates Postoperative Peritoneal Adhesion Formation by Enhancing Phosphorylation of the Chloride Channel-3.P-糖蛋白通过增强氯离子通道-3的磷酸化介导术后腹膜粘连形成。
Theranostics. 2016 Jan 1;6(2):204-18. doi: 10.7150/thno.13907. eCollection 2016.
8
Ghrelin ameliorates adhesions in a postsurgical mouse model.胃饥饿素可改善术后小鼠模型中的粘连情况。
J Surg Res. 2016 Mar;201(1):226-34. doi: 10.1016/j.jss.2015.10.044. Epub 2015 Nov 5.
9
Pathobiological mechanisms of peritoneal adhesions: The mesenchymal transition of rat peritoneal mesothelial cells induced by TGF-β1 and IL-6 requires activation of Erk1/2 and Smad2 linker region phosphorylation.腹膜粘连的病理生物学机制:TGF-β1和IL-6诱导的大鼠腹膜间皮细胞间充质转化需要激活Erk1/2和Smad2连接区磷酸化。
Matrix Biol. 2016 Apr;51:55-64. doi: 10.1016/j.matbio.2016.01.017. Epub 2016 Jan 26.
10
Advances in laparoscopy for acute care surgery and trauma.急性护理手术和创伤腹腔镜检查的进展。
World J Gastroenterol. 2016 Jan 14;22(2):668-80. doi: 10.3748/wjg.v22.i2.668.

血管疾病患者术后腹膜粘连的防治:文献综述

Prevention and treatment of peritoneal adhesions in patients affected by vascular diseases following surgery: a review of the literature.

作者信息

Rocca Aldo, Aprea Giovanni, Surfaro Giuseppe, Amato Maurizio, Giuliani Antonio, Paccone Marianna, Salzano Andrea, Russo Anna, Tafuri Domenico, Amato Bruno

机构信息

Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, Italy . Via Sergio Pansini, 80131 Naples, Italy.

Department of Clinical Medicine and Surgery, University of Naples Federico II, Italy.

出版信息

Open Med (Wars). 2016 Jun 23;11(1):106-114. doi: 10.1515/med-2016-0021. eCollection 2016.

DOI:10.1515/med-2016-0021
PMID:28352777
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5329808/
Abstract

Intra-abdominal adhesions are the most frequently occurring postoperative complication following abdomino-pelvic surgery. Abdominal and pelvic surgery can lead to peritoneal adhesion formation causing infertility, chronic pelvic pain, and intestinal obstruction. Laparoscopy today is considered the gold standard of care in the treatment of several abdominal pathologies as well as in a wide range of vascular diseases. Laparoscopy has several advantages in comparison to open surgery. These include rapid recovery times, shorter hospitalisation, reduced postoperative pain, as well as cosmetic benefits. The technological improvements in this particular surgical field along with the development of modern techniques and the acquisition of specific laparoscopic skills have allowed for its wider utilization in operations with fully intracorporeal anastomoses. Postoperative adhesions are caused by aberrant peritoneal healing and are the leading cause of postoperative bowel obstruction. The use of anti-adherence barriers is currently being advocated for their prevention. The outcome of the investigation showed adhesion formation inhibition without direct detrimental effects on anastomotic healing. Poor anasto-motic healing can provoke adhesions even in the presence of anti-adhesion barriers. This review gives a short overview on the current evidence on the pathophysiology and prevention of peritoneal adhesions.

摘要

腹腔内粘连是腹盆腔手术后最常见的术后并发症。腹部和盆腔手术可导致腹膜粘连形成,从而引起不孕、慢性盆腔疼痛和肠梗阻。如今,腹腔镜检查被认为是治疗多种腹部疾病以及多种血管疾病的金标准。与开放手术相比,腹腔镜检查有多个优点。这些优点包括恢复时间快、住院时间短、术后疼痛减轻以及具有美容效果。这一特定手术领域的技术进步以及现代技术的发展和特定腹腔镜技能的掌握,使得其在完全体内吻合手术中的应用更加广泛。术后粘连是由异常的腹膜愈合引起的,是术后肠梗阻的主要原因。目前主张使用抗粘连屏障来预防粘连。研究结果表明,抗粘连屏障可抑制粘连形成,且对吻合口愈合无直接有害影响。即使存在抗粘连屏障,吻合口愈合不良也可能引发粘连。本综述简要概述了目前关于腹膜粘连病理生理学和预防的证据。