Petti L, Kieff E
Kovler Viral Oncology Laboratory, University of Chicago, Illinois 60637.
J Virol. 1988 Jun;62(6):2173-8. doi: 10.1128/JVI.62.6.2173-2178.1988.
In the Epstein-Barr virus BamHI E genomic fragment, there are three distantly homologous long open reading frames, BERF1, BERF2b, and BERF4, each of which is preceded by a short open reading frame. The most leftward and most rightward short and long open reading frame pairs encode 145- and 155-kilodalton proteins in latently infected cells (EBNA3A and EBNA3C, respectively). In this report, we demonstrate that the middle long open reading frame, BERF2b, encodes part of a 165-kilodalton nuclear protein in every latently infected cell. Therefore, this protein is designated EBNA3B.
在爱泼斯坦-巴尔病毒BamHI E基因组片段中，存在三个远距离同源的长开放阅读框，即BERF1、BERF2b和BERF4，每个长开放阅读框之前都有一个短开放阅读框。最左边和最右边的短开放阅读框与长开放阅读框对在潜伏感染细胞中分别编码145千道尔顿和155千道尔顿的蛋白质（分别为EBNA3A和EBNA3C）。在本报告中，我们证明中间的长开放阅读框BERF2b在每个潜伏感染细胞中编码一种165千道尔顿核蛋白的一部分。因此，该蛋白被命名为EBNA3B。
