深入了解胶原蛋白在声带健康与疾病中的作用
Insights Into the Role of Collagen in Vocal Fold Health and Disease.
作者信息
Tang Sharon S, Mohad Vidisha, Gowda Madhu, Thibeault Susan L
机构信息
Department of Communication Sciences and Disorders, Department of Surgery, Division of Otolaryngology-Head & Neck Surgery, University of Wisconsin-Madison, Madison, Wisconsin.
Department of Surgery, Division of Otolaryngology-Head & Neck Surgery, University of Wisconsin-Madison, Madison, Wisconsin.
出版信息
J Voice. 2017 Sep;31(5):520-527. doi: 10.1016/j.jvoice.2017.01.008. Epub 2017 Mar 27.
Abstract
As one of the key fibrous proteins in the extracellular matrix, collagen plays a significant role in the structural and biomechanical characteristics of the vocal fold. Anchored fibrils of collagen create secure structural regions within the vocal folds and are strong enough to sustain vibratory impact and stretch during phonation. This contributes tensile strength, density, and organization to the vocal folds and influences health and pathogenesis. This review offers a comprehensive summary for a current understanding of collagen within normal vocal fold tissues throughout the life span as well as vocal pathology and wound repair. Further, collagen's molecular structure and biosynthesis are discussed. Finally, collagen alterations in tissue injury and repair and the incorporation of collagen-based biomaterials as a method of treating voice disorders are reviewed.
摘要
作为细胞外基质中的关键纤维蛋白之一，胶原蛋白在声带的结构和生物力学特性中发挥着重要作用。胶原蛋白的锚定纤维在声带内形成安全的结构区域，并且足够坚固，能够在发声过程中承受振动冲击和拉伸。这为声带提供了拉伸强度、密度和组织结构，并影响健康和发病机制。本综述全面总结了目前对正常声带组织在整个生命周期内的胶原蛋白以及声带病理学和伤口修复的理解。此外，还讨论了胶原蛋白的分子结构和生物合成。最后，综述了组织损伤和修复过程中胶原蛋白的变化，以及将基于胶原蛋白的生物材料作为治疗嗓音障碍方法的应用。
相似文献
1
Insights Into the Role of Collagen in Vocal Fold Health and Disease.深入了解胶原蛋白在声带健康与疾病中的作用
J Voice. 2017 Sep;31(5):520-527. doi: 10.1016/j.jvoice.2017.01.008. Epub 2017 Mar 27.
2
Insights into the role of elastin in vocal fold health and disease.弹性蛋白在声带健康和疾病中的作用研究进展。
J Voice. 2012 May;26(3):269-75. doi: 10.1016/j.jvoice.2011.05.003. Epub 2011 Jun 25.
3
A portable high-speed camera system for vocal fold examinations.一种用于声带检查的便携式高速摄像系统。
J Voice. 2014 Nov;28(6):681-7. doi: 10.1016/j.jvoice.2014.04.002. Epub 2014 Jul 5.
4
Threshold of oscillation of a vocal fold replica with unilateral surface growths.具有单侧表面生长的声带模型的振荡阈值。
J Acoust Soc Am. 2017 May;141(5):3050. doi: 10.1121/1.4979935.
5
Biomechanical and histologic observations of vocal fold fibrous proteins.声带纤维蛋白的生物力学和组织学观察
Ann Otol Rhinol Laryngol. 2000 Jan;109(1):77-85. doi: 10.1177/000348940010900115.
6
Mechanical characterization of vocal fold tissue: a review study.声带组织的力学特性：一项综述研究。
J Voice. 2014 Nov;28(6):657-67. doi: 10.1016/j.jvoice.2014.03.001. Epub 2014 Jul 5.
7
A generalized procedure for analyzing sustained and dynamic vocal fold vibrations from laryngeal high-speed videos using phonovibrograms.一种使用声振图从喉部高速视频分析持续和动态声带振动的通用程序。
Artif Intell Med. 2016 Jan;66:15-28. doi: 10.1016/j.artmed.2015.10.002. Epub 2015 Oct 30.
8
Treatment of aging vocal folds: novel approaches.衰老声带的治疗：新方法
Curr Opin Otolaryngol Head Neck Surg. 2014 Dec;22(6):472-6. doi: 10.1097/MOO.0000000000000096.
9
Use Videostrobokymography to Quantitatively Analyze the Vibratory Characteristics Before and After Conservative Medical Treatment of Vocal Fold Leukoplakia.使用频闪喉镜定量分析声带白斑保守药物治疗前后的振动特征。
J Voice. 2016 Mar;30(2):215-20. doi: 10.1016/j.jvoice.2015.04.015. Epub 2015 May 20.
10
Vibration stimulates vocal mucosa-like matrix expression by hydrogel-encapsulated fibroblasts.水凝胶包封成纤维细胞通过振动刺激类似声带黏膜的基质表达。
J Tissue Eng Regen Med. 2010 Jan;4(1):62-72. doi: 10.1002/term.219.
引用本文的文献
1
Novel application of bone marrow mesenchymal stem cells combined with hepatocyte growth factor on subacute vocal fold wound healing.骨髓间充质干细胞联合肝细胞生长因子在亚急性声带伤口愈合中的新应用
World J Otorhinolaryngol Head Neck Surg. 2024 Sep 16;11(2):264-275. doi: 10.1002/wjo2.215. eCollection 2025 Jun.
2
Genipin cross-linked gelatin hydrogel for encapsulating wharton jelly mesenchymal stem cells and basic fibroblast growth factor delivery in vocal fold regeneration.用于包裹华通氏胶间充质干细胞和在声带再生中递送碱性成纤维细胞生长因子的京尼平交联明胶水凝胶
Front Cell Dev Biol. 2024 Dec 5;12:1489901. doi: 10.3389/fcell.2024.1489901. eCollection 2024.
3
Localized delivery of therapeutics impact laryngeal mechanics, local inflammatory response, and respiratory microbiome following upper airway intubation injury in swine.局部递送治疗药物会影响猪上呼吸道插管损伤后的喉部力学、局部炎症反应和呼吸微生物组。
Respir Res. 2024 Sep 28;25(1):351. doi: 10.1186/s12931-024-02973-1.
4
High-Resolution Profiling of Human Vocal Fold Cellular Landscapes With Single-Nuclei RNA Sequencing.利用单核RNA测序对人声带细胞景观进行高分辨率分析
Laryngoscope. 2024 Jul;134(7):3193-3200. doi: 10.1002/lary.31334. Epub 2024 Feb 28.
5
Efficacy of platelet-rich plasma (PRP) in benign vocal fold lesions: a systematic review and meta-analysis.富血小板血浆（PRP）治疗良性声带病变的疗效：系统评价和荟萃分析。
Eur Arch Otorhinolaryngol. 2024 Jan;281(1):13-21. doi: 10.1007/s00405-023-08226-z. Epub 2023 Sep 14.
6
Sequence variants affecting voice pitch in humans.影响人类音高的序列变异。
Sci Adv. 2023 Jun 9;9(23):eabq2969. doi: 10.1126/sciadv.abq2969.
7
Tissue Engineering as a Promising Treatment for Glottic Insufficiency: A Review on Biomolecules and Cell-Laden Hydrogel.组织工程作为声门功能不全的一种有前景的治疗方法：生物分子和载细胞水凝胶综述
Biomedicines. 2022 Nov 30;10(12):3082. doi: 10.3390/biomedicines10123082.
8
The role of systemic dehydration in vocal fold healing: Preliminary findings.全身脱水在声带愈合中的作用：初步研究结果。
Laryngoscope Investig Otolaryngol. 2022 Oct 6;7(6):1936-1942. doi: 10.1002/lio2.942. eCollection 2022 Dec.
9
Proteomic analysis reveals that aging rabbit vocal folds are more vulnerable to changes caused by systemic dehydration.蛋白质组学分析表明，衰老的兔声带更容易受到全身脱水引起的变化的影响。
BMC Genomics. 2022 Nov 21;23(1):762. doi: 10.1186/s12864-022-08975-x.
10
Larynx proteomics after jellyfish collagen IL: Increased ECM/collagen and suppressed inflammation.水母胶原蛋白诱导后的喉蛋白质组学：细胞外基质/胶原蛋白增加且炎症受到抑制。
Laryngoscope Investig Otolaryngol. 2022 Sep 24;7(5):1513-1520. doi: 10.1002/lio2.924. eCollection 2022 Oct.
本文引用的文献
1
The efficacy of a novel collagen-gelatin scaffold with basic fibroblast growth factor for the treatment of vocal fold scar.一种新型含碱性成纤维细胞生长因子的胶原-明胶支架治疗声带瘢痕的疗效
J Tissue Eng Regen Med. 2017 May;11(5):1598-1609. doi: 10.1002/term.2060. Epub 2015 Jun 29.
2
Collagen hydrogels incorporated with surface-aminated mesoporous nanobioactive glass: Improvement of physicochemical stability and mechanical properties is effective for hard tissue engineering.表面接枝氨基介孔纳米生物活性玻璃的胶原水凝胶：改善物理化学稳定性和机械性能对硬组织工程有效。
Acta Biomater. 2013 Dec;9(12):9508-21. doi: 10.1016/j.actbio.2013.07.036. Epub 2013 Aug 6.
3
Visualizing collagen network within human and rhesus monkey vocal folds using polarized light microscopy.使用偏振光显微镜观察人类和恒河猴声带内的胶原网络。
Ann Otol Rhinol Laryngol. 2013 Feb;122(2):135-44. doi: 10.1177/000348941312200210.
4
Therapeutic potential of gel-based injectables for vocal fold regeneration.基于凝胶的注射剂在声带再生中的治疗潜力。
Biomed Mater. 2012 Apr;7(2):024103. doi: 10.1088/1748-6041/7/2/024103. Epub 2012 Mar 29.
5
The collagen family.胶原蛋白家族。
Cold Spring Harb Perspect Biol. 2011 Jan 1;3(1):a004978. doi: 10.1101/cshperspect.a004978.
6
Morphological and extracellular matrix changes following vocal fold injury in mice.在体声音带损伤后形态学和细胞外基质的变化。
Cells Tissues Organs. 2010;192(4):262-71. doi: 10.1159/000315476. Epub 2010 May 27.
7
Collagen type I hydrogel allows migration, proliferation, and osteogenic differentiation of rat bone marrow stromal cells.I 型胶原水凝胶允许大鼠骨髓基质细胞的迁移、增殖和成骨分化。
J Biomed Mater Res A. 2010 Aug;94(2):442-9. doi: 10.1002/jbm.a.32696.
8
Alteration in cellular morphology, density and distribution in rat vocal fold mucosa following injury.大鼠声带黏膜损伤后细胞形态、密度和分布的改变。
Wound Repair Regen. 2010 Jan-Feb;18(1):89-97. doi: 10.1111/j.1524-475X.2009.00550.x. Epub 2009 Dec 11.
9
Mesenchymal stromal cells: current understanding and clinical status.间质基质细胞：当前的认识和临床状况。
Stem Cells. 2010 Mar 31;28(3):585-96. doi: 10.1002/stem.269.
10
The presence of a vocal ligament in fetuses: a histochemical and ultrastructural study.胎儿声带的存在：一项组织化学和超微结构研究。
J Anat. 2009 Dec;215(6):692-7. doi: 10.1111/j.1469-7580.2009.01146.x.
Zotero 插件