Translational Oncology, Department of Otorhinolaryngology, University Hospital Essen, Essen, Germany; and
Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, The Hebrew University Hadassah Medical School, Jerusalem, Israel
J Leukoc Biol. 2017 Sep;102(3):685-688. doi: 10.1189/jlb.3MR0117-015R. Epub 2017 Mar 30.
Neutrophils were traditionally considered to be a homogeneous population of terminally differentiated cells with very defined roles in inflammation and fighting infections. However, recent advances in neutrophil research challenge this limited view and demonstrate that neutrophils are highly versatile, play different roles in various pathologic scenarios, and are heterogeneous. With this, it is becoming clear that one term-"neutrophil"-is too general, and more precise nomenclature is urgently required. In this mini review, we discuss the knowns and unknowns in neutrophil terminology and highlight the critical questions that should be addressed for the establishment of clear neutrophil nomenclature.
中性粒细胞传统上被认为是一种终末分化的细胞同质群体，在炎症和抗感染中具有非常明确的作用。然而，中性粒细胞研究的最新进展挑战了这种有限的观点，并表明中性粒细胞具有高度的多功能性，在各种病理情况下发挥不同的作用，并且具有异质性。由此可见，一个术语——“中性粒细胞”——过于笼统，迫切需要更精确的命名法。在这篇迷你综述中，我们讨论了中性粒细胞术语的已知和未知，并强调了为建立明确的中性粒细胞命名法而应解决的关键问题。
