唾液前列腺素 E2：在蜱虫引起的红肉过敏中的作用。
Salivary Prostaglandin E2: Role in Tick-Induced Allergy to Red Meat.
机构信息
Institute of Parasitology, Biology Center of the Academy of Sciences of the Czech Republic, 37005 České Budějovice, Czech Republic; Faculty of Science, University of South Bohemia, 37005 České Budějovice, Czech Republic.
SaBio. Instituto de Investigación de Recursos Cinegéticos, IREC-CSIC-UCLM-JCCM, 13005 Ciudad Real, Spain.
出版信息
Trends Parasitol. 2017 Jul;33(7):495-498. doi: 10.1016/j.pt.2017.03.004. Epub 2017 Mar 30.
Tick-induced allergy to red meat is associated with anti-α-Gal IgE antibody levels. We propose that tick salivary prostaglandin E2 triggers antibody class switching in mature B cells, increasing the levels of anti-α-Gal IgE antibodies. Immune tolerance to α-Gal in blood type B individuals might reduce the risk to this allergy.
蜱虫引起的红肉过敏与抗α-Gal IgE 抗体水平有关。我们提出，蜱虫唾液中的前列腺素 E2 可触发成熟 B 细胞中的抗体类别转换，增加抗α-Gal IgE 抗体的水平。B 型血个体对α-Gal 的免疫耐受可能会降低这种过敏的风险。
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