Granéli Christina, Dahlin Eero, Börjesson Anna, Arnbjörnsson Einar, Stenström Pernilla
Department of Pediatric Surgery, Skåne University Hospital and Institution of Clinical Research, Lund University, Lund, Sweden.
Surg Res Pract. 2017;2017:9274940. doi: 10.1155/2017/9274940. Epub 2017 Mar 7.
. Hirschsprung's disease (HD) has a skewed gender distribution, with a female to male ratio of 1 : 4. This study aims to examine differences between boys and girls with HD regarding preoperative features and postoperative treatment and outcome. . The first part of the study was conducted as a retrospective review of all HD patients who underwent transanal endorectal pull-through (TERPT). Pre-, peri-, immediate post-, and first-year postoperative data were collected. The second part was conducted as an observational cross-sectional study by comparing bowel function scores (BFS) determined by structured interviews of patients 4 years old and older. . Included were 39 boys and 12 girls. Of these, 25 boys and 9 girls were older than 4 years and participated in the BFS interview. Boys had a higher frequency of hospitalizations during the first postoperative year compared to girls ( = 20 and = 2, < 0.05). At long-term follow-up, more boys reported abnormal frequency of defecation, 16 compared to 2 ( < 0.05). There was no difference between genders in terms of preoperative symptoms and overall bowel function later. . Boys with HD had more hospitalizations and a higher rate of abnormal frequency of defecation than girls with HD.
先天性巨结肠（HD）存在性别分布不均衡的情况，女性与男性的比例为1∶4。本研究旨在探讨患HD的男孩和女孩在术前特征、术后治疗及预后方面的差异。本研究的第一部分是对所有接受经肛门直肠内拖出术（TERPT）的HD患者进行回顾性分析。收集术前、术中、术后即刻及术后第一年的数据。第二部分是通过比较4岁及以上患者经结构化访谈确定的肠功能评分（BFS）进行观察性横断面研究。纳入39名男孩和12名女孩。其中，25名男孩和9名女孩年龄超过4岁并参与了BFS访谈。与女孩相比，男孩在术后第一年的住院频率更高（分别为20次和2次，P<0.05）。在长期随访中，报告排便频率异常的男孩更多，分别为16名和2名（P<0.05）。术前症状和后期整体肠功能在性别方面无差异。患HD的男孩比患HD的女孩住院次数更多，排便频率异常率更高。
