含有同源病毒的甲型流感病毒/马/迈阿密/63（H3N8）灭活全病毒疫苗对实验性感染的防护作用。
Protection against experimental infection with influenza virus A/equine/Miami/63 (H3N8) provided by inactivated whole virus vaccines containing homologous virus.
作者信息
Mumford J A, Wood J M, Folkers C, Schild G C
机构信息
Equine Virology Unit, Animal Health Trust, Newmarket, Suffolk.
出版信息
Epidemiol Infect. 1988 Jun;100(3):501-10. doi: 10.1017/s0950268800067236.
Abstract
Thirty-one ponies immunized with inactivated virus vaccine containing A/equine/Miami/63 (H3N8) virus and six seronegative ponies were experimentally challenged with the homologous virus strain. All 6 unvaccinated ponies and 11 out of 31 vaccinated ponies became infected. A clear relationship between pre-challenge antibody, measured by single radial haemolysis (SRH), and protection was demonstrated as judged by virus excretion, febrile responses and antibody responses. Those ponies with SRH antibody levels greater than 74 mm2 were completely protected against challenge infection by the intranasal route.
摘要
用含有A/equine/Miami/63（H3N8）病毒的灭活病毒疫苗免疫31匹小马，并对6匹血清阴性小马用同源病毒株进行实验性攻毒。所有6匹未接种疫苗的小马和31匹接种疫苗的小马中的11匹被感染。通过单次放射溶血法（SRH）测定的攻毒前抗体与保护之间存在明显关系，这通过病毒排泄、发热反应和抗体反应来判断。SRH抗体水平大于74平方毫米的小马通过鼻内途径完全受到保护，免受攻毒感染。
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本文引用的文献
1
The standardization of inactivated equine influenza vaccines by single-radial immunodiffusion.
J Biol Stand. 1983 Apr;11(2):133-6. doi: 10.1016/s0092-1157(83)80037-7.
2
Interpretation of responses and protective levels of antibody against attenuated influenza A viruses using single radial haemolysis.利用单向辐射溶血法解读针对减毒甲型流感病毒的抗体反应及保护水平
J Hyg (Lond). 1984 Oct;93(2):301-12. doi: 10.1017/s0022172400064834.
3
The use of the single radial haemolysis test for assessing antibody response and protective antibody levels in an influenza B vaccine study.
J Biol Stand. 1983 Oct;11(4):289-96. doi: 10.1016/s0092-1157(83)80017-1.
4
Studies with inactivated equine influenza vaccine. 1. Serological responses of ponies to graded doses of vaccine.灭活马流感疫苗的研究。1. 小马对不同剂量疫苗的血清学反应。
J Hyg (Lond). 1983 Jun;90(3):371-84. doi: 10.1017/s0022172400029004.
5
Studies with inactivated equine influenza vaccine. 2. Protection against experimental infection with influenza virus A/equine/Newmarket/79 (H3N8).马流感灭活疫苗的研究。2. 针对A/马/纽马基特/79（H3N8）流感病毒实验性感染的防护作用
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6
Biological properties of an influenza A virus-specific killer T cell clone. Inhibition of virus replication in vivo and induction of delayed-type hypersensitivity reactions.甲型流感病毒特异性杀伤性T细胞克隆的生物学特性。体内病毒复制的抑制及迟发型超敏反应的诱导。
J Exp Med. 1981 Aug 1;154(2):225-34. doi: 10.1084/jem.154.2.225.
7
8
Clinical studies of monovalent inactivated whole virus and subunit A/USSR/77 (H1N1) vaccine: serological responses and clinical reactions.单价灭活全病毒及亚单位A/苏联/77（H1N1）疫苗的临床研究：血清学反应及临床反应
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