Department of Sport, Exercise and Health, Division Sports and Exercise Medicine, University of Basel, Basel, Switzerland.
Department of Sport, Exercise and Health, Division Sports and Exercise Medicine, University of Basel, Basel, Switzerland.
Atherosclerosis. 2018 May;272:21-26. doi: 10.1016/j.atherosclerosis.2018.03.014. Epub 2018 Mar 8.
Higher cardiorespiratory fitness is associated with lower pulse wave velocity and arterial stiffness in normal weight individuals, and this has not been examined in obese individuals. It is unclear whether an altered body composition acts as a modifier of the association between cardiorespiratory fitness and arterial stiffness. We examined the association between peak oxygen uptake and brachial-ankle pulse wave velocity and analysed whether body composition attenuates this association in obese middle-aged individuals.
Bio-impedance analysis-derived body composition assessment in 212 healthy and sedentary either overweight or obese individuals was followed by measurement of brachial-ankle pulse wave velocity and spiroergometric peak oxygen uptake. Multivariate analysis was performed to analyse the association between peak oxygen uptake and brachial-ankle pulse wave velocity and to assess the moderating effect of several body composition-related interaction terms (BMI, total body mass, body fat mass, waist circumference, waist-to-height ratio) on this association.
Peak oxygen uptake was inversely associated with brachial-ankle pulse wave velocity (β = -0.059, 95% CI = -0.099; -0.018, p = 0.005). Testing for the impact of different body composition-related interaction terms on this association showed no significance, 95% CI lateralized towards positivity.
This study shows an inverse association between cardiorespiratory fitness and arterial stiffness in middle-aged obese individuals. We also found a tendency towards an attenuating impact of an obese body composition on this association. Physical fitness seems to be a stronger modulator of cardiovascular risk than body composition but the success of training efforts may be compromised by obesity.
在体重正常的人群中，较高的心肺适能与较低的脉搏波速度和动脉僵硬相关，而在肥胖人群中尚未对此进行研究。目前尚不清楚改变的身体成分是否会影响心肺适能与动脉僵硬之间的关联。我们研究了峰值摄氧量与肱踝脉搏波速度之间的关系，并分析了肥胖中年个体的身体成分是否会减弱这种关联。
对 212 名健康且久坐的超重或肥胖个体进行生物电阻抗分析评估身体成分，随后测量肱踝脉搏波速度和运动心肺功能峰值摄氧量。采用多元分析来分析峰值摄氧量与肱踝脉搏波速度之间的关联，并评估几个与身体成分相关的交互项（BMI、总体体重、体脂肪量、腰围、腰高比）对这种关联的调节作用。
峰值摄氧量与肱踝脉搏波速度呈负相关（β= -0.059，95%CI = -0.099；-0.018，p=0.005）。对不同与身体成分相关的交互项对这种关联的影响进行检验，结果无统计学意义，95%CI 偏向正值。
本研究表明，在中年肥胖个体中，心肺适能与动脉僵硬之间呈负相关。我们还发现，肥胖的身体成分对这种关联有减弱的趋势。身体活动似乎是心血管风险的一个更强的调节因素，而不是身体成分，但肥胖可能会影响训练效果。
