Collins Brittany, Breithaupt Lauren, McDowell Jennifer E, Miller L Stephen, Thompson James, Fischer Sarah
Department of Pediatric Neuropsychology, National Medical Center.
Department of Psychology, George Mason University.
J Abnorm Psychol. 2017 Jul;126(5):540-551. doi: 10.1037/abn0000242.
The impact of acute stress on the neural processing of food cues in bulimia nervosa (BN) is unknown, despite theory that acute stress decreases cognitive control over food and hence increases vulnerability to environmental triggers for binge eating. Thus, the goals of this manuscript were to explore the impact of acute stress on the neural processing of food cues in BN. In Study 1, 10 women with Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5; American Psychiatric Association, 2013) BN and 10 healthy controls participated in an fMRI paradigm examining the neural correlates of visual food cue processing pre and post an acute stress induction. Whole brain analysis indicated that women with BN exhibited significant decreases in activation in the precuneus, associated with self-referential processing, the paracingulate gyrus, and the anterior vermis of the cerebellum. Healthy controls exhibited increased activation in these regions in response to food cues poststress. In Study 2, 17 women with DSM-5 BN or otherwise specified feeding and eating disorder with BN symptoms participated in the same paradigm. A region of interest analysis replicated findings from Study 1. Replication of imaging findings in 2 different samples suggests the potential importance of these regions in relation to BN. Decreased activation in the precuneus, specifically, is consistent with models of BN that posit that binge eating serves as a concrete distraction from aversive internal stimuli. (PsycINFO Database Record
尽管有理论认为急性应激会降低对食物的认知控制，从而增加暴饮暴食的环境诱因，但急性应激对神经性贪食症（BN）患者食物线索神经加工的影响尚不清楚。因此，本论文的目的是探讨急性应激对BN患者食物线索神经加工的影响。在研究1中，10名符合《精神疾病诊断与统计手册》（第5版；DSM-5；美国精神病学协会，2013）中BN诊断标准的女性和10名健康对照者参与了一项功能磁共振成像（fMRI）实验，该实验检测了急性应激诱导前后视觉食物线索加工的神经相关性。全脑分析表明，BN组女性在楔前叶（与自我参照加工有关）、扣带旁回和小脑前叶蚓部的激活显著降低。健康对照组在应激后对食物线索的反应中，这些区域的激活增加。在研究2中，17名符合DSM-5中BN诊断标准或患有其他特定的进食与喂养障碍且伴有BN症状的女性参与了相同的实验。感兴趣区域分析重复了研究1的结果。在两个不同样本中重复成像结果表明了这些区域与BN的潜在重要关系。具体而言，楔前叶激活降低与BN的模型一致，该模型认为暴饮暴食是对厌恶的内部刺激的一种具体转移方式。（PsycINFO数据库记录
