3克燕麦可溶性纤维对亚洲印度人血脂水平的影响——一项随机对照平行组研究。
Effects of 3 g of soluble fiber from oats on lipid levels of Asian Indians - a randomized controlled, parallel arm study.
作者信息
Gulati Seema, Misra Anoop, Pandey Ravindra M
机构信息
Diabetes Foundation (India), Safdarjung Development Area, New Delhi, India.
National Diabetes, Obesity, and Cholesterol Foundation (N-DOC), Safdarjung Development Area, New Delhi, India.
出版信息
Lipids Health Dis. 2017 Apr 4;16(1):71. doi: 10.1186/s12944-017-0460-3.
BACKGROUND
Cardiovascular diseases are more prevalent and severe in Asian Indians. Simple diet-based strategies are important for prevention of cardiovascular diseases.The aim of the present study was to evaluate the effects of oats consumption on lipid parameters in mildly hypercholesterolemic Asian Indians living in India.
METHODS
A short-term, prospective, open-labeled, randomized controlled, parallel group study was conducted. Mildly hypercholesterolemic (total cholesterol >200 mg/dL and <240 mg/dL) subjects (n = 80) were randomized into two groups: intervention (n = 40) and usual diet (n = 40). Sample size was calculated for a two-group parallel superiority randomized control trial. Out of 80 enrolled subjects 69 subjects completed the study; 33 in the control group and 36 in the intervention group. In the intervention group, patients were served 70 g of oats twice a day in the form of porridge and upma (A thick porridge from oats with seasonings and vegetables) under observation at the study site. Lipid parameters were assessed at baseline and after 4 weeks of intervention.
RESULTS
There was a reduction of 3.1% in total cholesterol levels in the control group as against 8.1% reduction in the intervention group (p < 0.02). Greater reductions were also seen in low-density lipoprotein cholesterol in the intervention group (11.6%) as compared to control group (4.1%, p < 0.04) over a period of 28 days.
CONCLUSION
Daily consumption of 3 g of soluble fiber from 70 g of oats leads to beneficial effects on the lipid parameters, specifically total cholesterol and low-density lipoprotein cholesterol in hypercholesterolemic Asian Indians. Large scale studies over a longer period of intervention are required to further establish the cholesterol-lowering effect of oat fiber.
TRIAL REGISTRATION
The study was retrospectively registered at clinicaltrials.gov (dated: 25th Februrary.2015) with registration number NCT02376660 .
背景
心血管疾病在亚洲印度人群中更为普遍和严重。基于饮食的简单策略对预防心血管疾病很重要。本研究的目的是评估食用燕麦对生活在印度的轻度高胆固醇血症亚洲印度人血脂参数的影响。
方法
进行了一项短期、前瞻性、开放标签、随机对照、平行组研究。轻度高胆固醇血症（总胆固醇>200mg/dL且<240mg/dL）受试者（n = 80）被随机分为两组：干预组（n = 40）和常规饮食组（n = 40）。样本量是为两组平行优效性随机对照试验计算的。在80名入组受试者中，69名受试者完成了研究；对照组33名，干预组36名。在干预组，患者在研究地点接受观察时，每天以粥和乌普马（一种加了调味料和蔬菜的燕麦稠粥）的形式食用70克燕麦两次。在基线和干预4周后评估血脂参数。
结果
对照组总胆固醇水平降低了3.1%，而干预组降低了8.1%（p < 0.02）。在28天的时间里，干预组低密度脂蛋白胆固醇的降低幅度也大于对照组（11.6%对4.1%，p < 0.04）。
结论
每天从70克燕麦中摄入3克可溶性纤维对血脂参数有有益影响，特别是对高胆固醇血症亚洲印度人的总胆固醇和低密度脂蛋白胆固醇。需要进行更长时间干预的大规模研究来进一步确定燕麦纤维的降胆固醇效果。
试验注册
该研究于2015年2月25日在clinicaltrials.gov上进行了回顾性注册，注册号为NCT02376660。
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