Food Research Division, Bureau of Chemical Safety, Health Products and Food Branch, Health Canada, Sir Frederick Banting Research Centre, 251 Sir Frederick Banting Driveway, 2203C, Tunney's Pasture, Ottawa, ON K1A 0K9, Canada.
Food Research Division, Bureau of Chemical Safety, Health Products and Food Branch, Health Canada, Sir Frederick Banting Research Centre, 251 Sir Frederick Banting Driveway, 2203C, Tunney's Pasture, Ottawa, ON K1A 0K9, Canada.
Sci Total Environ. 2017 Oct 1;595:269-278. doi: 10.1016/j.scitotenv.2017.03.157. Epub 2017 Apr 4.
Human milk was collected between 2008 and 2011 as part of the Maternal - Infant Research on Environmental Chemicals (MIREC) study that was initiated to establish Canadian national estimates of maternal and infant exposure to a broad suite of environmental contaminants (e.g., persistent organic pollutants [POPs], trace elements, phthalates, etc.). Among the 1017 human milk samples collected, 298 were analysed for polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs) and polychlorinated biphenyls (PCBs). World Health Organization (WHO) toxic equivalency concentrations (WHO TEQ) for PCDD/F+dioxin-like (DL) PCB ranged from 2.2pg TEQ g lipid to 27pg TEQ g lipid. The relative contribution of PCDDs to the overall WHO TEQ (PCDD/F+DL PCB) has decreased from earlier investigations into POP levels in Canadian human milk. Significantly higher PCB concentrations were observed in milk from women born in Europe relative to those born in Canada (p<0.001), in contrast to results for the PCDD/Fs (p=0.496). Age was found to significantly impact milk ∑PCB concentrations (p=0.018), with elevated concentrations observed in milk from women >30years relative to those <30years of age. While this trend was also observed for the PCDD/Fs, this relationship was impacted by parity. WHO TEQ concentrations were significantly higher in milk from primiparous women (p=0.019) and those >30years relative to those <30years of age (p<0.001). No significant differences were associated with education level or pre-pregnancy body mass index. PCB and PCDD/F concentrations have continued to decline in Canadian human milk since the last sampling of human milk was performed.
人乳采集于 2008 年至 2011 年期间，是“母婴环境化学污染物研究”（MIREC）的一部分。该研究旨在建立加拿大全国母婴人群对广泛环境污染物（如持久性有机污染物[POPs]、微量元素、邻苯二甲酸酯等）暴露的估计值。在收集的 1017 个人乳样本中，有 298 个样本分析了多氯二苯并对二恶英（PCDDs）、二苯并呋喃（PCDFs）和多氯联苯（PCBs）。多氯二苯并对二恶英/呋喃（PCDD/F）和类二恶英多氯联苯（DL-PCB）的世界卫生组织（WHO）毒性等效浓度（WHO-TEQ）范围为 2.2pg TEQ/g 脂质至 27pg TEQ/g 脂质。PCDDs 对 WHO-TEQ（PCDD/F+DL-PCB）的相对贡献已从加拿大人乳中 POP 水平的早期研究中降低。与 PCDDFs 的结果相反（p=0.496），出生于欧洲的妇女的人乳中 PCB 浓度明显高于出生于加拿大的妇女（p<0.001）。年龄发现对人乳∑PCB 浓度有显著影响（p=0.018），大于 30 岁的妇女的人乳中浓度高于 30 岁以下的妇女。虽然这种趋势也观察到了 PCDDFs，但这种关系受到产次的影响。与小于 30 岁的妇女相比，初次生育的妇女（p=0.019）和大于 30 岁的妇女的人乳中 WHO-TEQ 浓度显著更高（p<0.001）。教育水平或孕前体重指数与浓度无显著差异。自上次采集人乳以来，加拿大人乳中的 PCB 和 PCDD/F 浓度继续下降。
