Moghimi S, Afzali M, Akbari M, Ebrahimi K B, Khodabande A, Yazdani-Abyaneh A R, Ghafouri S N H, Coh P, Okhravi S, Fard M A
Farabi Eye Hospital, Eye Research Center, Tehran University of Medical Science, Tehran, Iran.
Koret Vision Center, University of California, San Francisco, CA, USA.
Eye (Lond). 2017 Aug;31(8):1191-1198. doi: 10.1038/eye.2017.56. Epub 2017 Apr 7.
PurposeTo characterize the optic nerve head (ONH) structure in patients with non-arteritic anterior ischemic optic neuropathy (NAION) compared to healthy control subjects using spectral domain optical coherence tomography (SD-OCT) via the enhanced depth imaging method.MethodsIn this prospective, cross-sectional, comparative study, we assessed 66 eyes of 33 patients with unilateral NAION and 31 eyes of 31 healthy normal subjects in an academic institution. The peripapillary nerve fiber layer thickness, disc area, and quantitative parameters of the ONH structures, including the Bruch's membrane opening (BMO) area, anterior laminar depth, and prelaminar thickness and depth were compared between the three groups.ResultsLinear mixed model analysis after adjusting for age, sex, and axial length showed that the BMO area was similar in eyes with NAION (1.89±0.33 mm), their fellow eyes (1.85±0.35 mm), and control eyes (1.88±0.37 mm; all P>0.99). Anterior laminar depth was also similar in the three groups. The mean prelaminar tissue thickness of the NAION eyes was 445±176 μm, which was thinner than the prelaminar tissue of their unaffected fellow eyes (mean, 539±227 μm, P=0.004), but both were thicker than the prelaminar tissue of the normal subjects (mean 243±145 μm, P=0.001 and P<0.001, respectively).ConclusionsThe thick prelaminar thickness is associated with unilateral NAION in the affected and unaffected eyes.
目的
使用增强深度成像方法的光谱域光学相干断层扫描（SD-OCT），对比非动脉炎性前部缺血性视神经病变（NAION）患者与健康对照者的视神经乳头（ONH）结构。
方法
在这项前瞻性、横断面、对比研究中，我们在一所学术机构评估了33例单侧NAION患者的66只眼以及31名健康正常受试者的31只眼。比较了三组之间的视乳头周围神经纤维层厚度、视盘面积以及ONH结构的定量参数，包括布鲁赫膜开口（BMO）面积、前板层深度以及板层前厚度和深度。
结果
在对年龄、性别和眼轴长度进行校正后的线性混合模型分析显示，NAION患眼（1.89±0.33 mm）、对侧眼（1.85±0.35 mm）和对照眼（1.88±0.37 mm；所有P>0.99）的BMO面积相似。三组的前板层深度也相似。NAION患眼的平均板层前组织厚度为445±176 μm，比未受影响的对侧眼的板层前组织薄（平均为539±227 μm，P=0.004），但两者均比正常受试者的板层前组织厚（平均为243±145 μm，P分别为0.001和P<0.001）。
结论
增厚的板层前厚度与患眼及对侧眼中的单侧NAION相关。
