黄酮类化合物的抗病毒活性及抗坏血酸盐的增效作用。
Antiviral activity of flavones and potentiation by ascorbate.
作者信息
Vrijsen R, Everaert L, Boeyé A
机构信息
Department of Microbiology and Hygiene, Vrije Universiteit Brussel, Belgium.
出版信息
J Gen Virol. 1988 Jul;69 ( Pt 7):1749-51. doi: 10.1099/0022-1317-69-7-1749.
PMID:2839607
Abstract
We compared the anti-poliovirus activities of three flavones, quercetin, luteolin and 3-methylquercetin, which differ only at ring position 3. 3-Methylquercetin was the most potent compound. Quercetin exhibited antiviral activity only when protected against oxidative degradation by ascorbate. The antiviral activity of luteolin was comparable to that of ascorbate-stabilized quercetin.
摘要
我们比较了三种仅在3位环位置不同的黄酮类化合物（槲皮素、木犀草素和3 - 甲基槲皮素）的抗脊髓灰质炎病毒活性。3 - 甲基槲皮素是最有效的化合物。槲皮素只有在被抗坏血酸保护免受氧化降解时才表现出抗病毒活性。木犀草素的抗病毒活性与抗坏血酸稳定的槲皮素相当。
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